Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1145559..1146052 Replicon chromosome
Accession NZ_CP006030
Organism Enterococcus faecium T110

Toxin (Protein)


Gene name relE Uniprot ID J6KIM0
Locus tag M395_RS05555 Protein ID WP_002400299.1
Coordinates 1145786..1146052 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4Y3JLV3
Locus tag M395_RS05550 Protein ID WP_025478324.1
Coordinates 1145559..1145789 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M395_RS05525 1141808..1142575 + 768 WP_002400309.1 MurR/RpiR family transcriptional regulator -
M395_RS05530 1142576..1143019 + 444 WP_002400306.1 hypothetical protein -
M395_RS05535 1143228..1143818 - 591 WP_002400305.1 glutamine amidotransferase -
M395_RS14045 1144431..1144733 + 303 Protein_1092 hypothetical protein -
M395_RS14050 1144913..1145068 + 156 WP_002400302.1 hypothetical protein -
M395_RS05550 1145559..1145789 + 231 WP_025478324.1 hypothetical protein Antitoxin
M395_RS05555 1145786..1146052 + 267 WP_002400299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M395_RS05560 1146303..1146531 + 229 Protein_1096 hypothetical protein -
M395_RS05565 1146547..1147713 + 1167 WP_002314829.1 oxygen-independent coproporphyrinogen III oxidase -
M395_RS05570 1147947..1148990 + 1044 WP_002294449.1 heat-inducible transcriptional repressor HrcA -
M395_RS05575 1149084..1149647 + 564 WP_002400298.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10642.41 Da        Isoelectric Point: 10.4982

>T45194 WP_002400299.1 NZ_CP006030:1145786-1146052 [Enterococcus faecium T110]
MTYRLEFTPEIQKQLRKMDKHQAMLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDKQLVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T45194 NZ_CP006030:1145786-1146052 [Enterococcus faecium T110]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGATGCTGATCGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATAAACAATTGGTTGTTATCGCTATTCAAGTA
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8790.97 Da        Isoelectric Point: 4.4723

>AT45194 WP_025478324.1 NZ_CP006030:1145559-1145789 [Enterococcus faecium T110]
MAMITVRVSDAEKEWLSYMAKFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLG

Download         Length: 231 bp

>AT45194 NZ_CP006030:1145559-1145789 [Enterococcus faecium T110]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGAAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCTATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y3JQ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y3JLV3

References