Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1236129..1236627 Replicon chromosome
Accession NZ_CP006009
Organism Rickettsia rickettsii str. R

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3AWA1
Locus tag RRR_RS06560 Protein ID WP_012151451.1
Coordinates 1236484..1236627 (+) Length 48 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID H8LNX5
Locus tag RRR_RS06555 Protein ID WP_012151450.1
Coordinates 1236129..1236392 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RRR_RS08020 1231379..1231495 + 117 WP_080508248.1 palindromic element RPE1 domain-containing protein -
RRR_RS06515 1231547..1232242 - 696 WP_012151442.1 TIGR02281 family clan AA aspartic protease -
RRR_RS06520 1232303..1232521 - 219 WP_012151443.1 serine hydrolase -
RRR_RS08480 1233082..1233243 - 162 WP_012262644.1 serine hydrolase -
RRR_RS06535 1233439..1233678 - 240 WP_012151447.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
RRR_RS06540 1233883..1234605 - 723 WP_010977895.1 amino acid ABC transporter ATP-binding protein -
RRR_RS06545 1234609..1235373 - 765 WP_012151448.1 MBL fold metallo-hydrolase -
RRR_RS06550 1235388..1236035 + 648 WP_012151449.1 phosphatase PAP2 family protein -
RRR_RS06555 1236129..1236392 + 264 WP_012151450.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
RRR_RS06560 1236484..1236627 + 144 WP_012151451.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
RRR_RS06565 1236763..1237845 + 1083 WP_014362438.1 LptF/LptG family permease -
RRR_RS06570 1237851..1238315 - 465 WP_012151453.1 DNA polymerase III subunit chi -
RRR_RS06580 1238515..1239660 - 1146 WP_012151455.1 succinyl-diaminopimelate desuccinylase -
RRR_RS06585 1239664..1239918 - 255 WP_012151456.1 restriction endonuclease subunit S -
RRR_RS08485 1240222..1240422 - 201 WP_155105224.1 restriction endonuclease subunit S -
RRR_RS06590 1240418..1240609 - 192 WP_014362439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-45)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5357.17 Da        Isoelectric Point: 6.4361

>T45163 WP_012151451.1 NZ_CP006009:1236484-1236627 [Rickettsia rickettsii str. R]
MRDHALIGNWKDCRDCHIKADLVLIYRKPDADTLELIQLGSNSTLGF

Download         Length: 144 bp

>T45163 NZ_CP006009:1236484-1236627 [Rickettsia rickettsii str. R]
ATGAGAGATCATGCCCTTATAGGTAATTGGAAAGATTGTAGAGATTGTCATATTAAAGCGGATTTAGTATTAATTTATAG
AAAACCCGATGCTGACACATTGGAGTTAATACAATTAGGTTCAAACAGTACACTTGGTTTTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9516.03 Da        Isoelectric Point: 5.0916

>AT45163 WP_012151450.1 NZ_CP006009:1236129-1236392 [Rickettsia rickettsii str. R]
MSADSIVRARINEDVKEEAALVLAAMGLTLSDAVRMLLFRVAREKALPFEPLIPNDETIKAMKAARSGKLVHVGNINNLL
SDLNEND

Download         Length: 264 bp

>AT45163 NZ_CP006009:1236129-1236392 [Rickettsia rickettsii str. R]
ATGTCTGCTGATTCTATTGTGCGAGCCCGTATTAATGAAGACGTGAAAGAAGAAGCAGCTTTAGTGCTTGCTGCTATGGG
ACTTACTTTATCTGATGCTGTTCGTATGCTGTTATTTCGTGTTGCTCGTGAAAAAGCATTGCCGTTTGAACCACTTATCC
CAAATGATGAAACAATTAAAGCTATGAAAGCTGCAAGAAGCGGCAAATTAGTTCATGTTGGTAATATCAATAATTTGTTA
TCTGATTTAAATGAGAACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AWA1

Antitoxin

Source ID Structure
AlphaFold DB H8LNX5

References