Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 98413..99451 | Replicon | chromosome |
| Accession | NZ_CP005986 | ||
| Organism | Acidithiobacillus caldus ATCC 51756 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | ACAty_RS00455 | Protein ID | WP_004869854.1 |
| Coordinates | 98413..98985 (-) | Length | 191 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A1M4YH97 |
| Locus tag | ACAty_RS00460 | Protein ID | WP_004869856.1 |
| Coordinates | 98990..99451 (-) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACAty_RS00430 | 93634..94017 | - | 384 | WP_004869841.1 | hypothetical protein | - |
| ACAty_RS00435 | 94014..95393 | - | 1380 | WP_004869844.1 | recombinase family protein | - |
| ACAty_RS00440 | 95393..95836 | - | 444 | WP_004869845.1 | DUF2924 domain-containing protein | - |
| ACAty_RS00445 | 95836..96027 | - | 192 | WP_004869848.1 | hypothetical protein | - |
| ACAty_RS00450 | 96132..98387 | - | 2256 | WP_004869851.1 | hypothetical protein | - |
| ACAty_RS00455 | 98413..98985 | - | 573 | WP_004869854.1 | PIN domain-containing protein | Toxin |
| ACAty_RS00460 | 98990..99451 | - | 462 | WP_004869856.1 | helix-turn-helix domain-containing protein | Antitoxin |
| ACAty_RS00465 | 99678..99941 | + | 264 | WP_004869858.1 | DNA-binding protein | - |
| ACAty_RS00470 | 99952..100431 | + | 480 | WP_004869861.1 | hypothetical protein | - |
| ACAty_RS00475 | 100435..101208 | + | 774 | WP_004869863.1 | Bro-N domain-containing protein | - |
| ACAty_RS00480 | 101208..102038 | + | 831 | WP_004869865.1 | ATP-binding protein | - |
| ACAty_RS00485 | 102042..102668 | + | 627 | WP_004869867.1 | hypothetical protein | - |
| ACAty_RS00490 | 102732..103253 | + | 522 | WP_038471353.1 | hypothetical protein | - |
| ACAty_RS00495 | 103250..103996 | + | 747 | WP_004869870.1 | hypothetical protein | - |
| ACAty_RS00500 | 103993..104247 | + | 255 | WP_038471357.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 90671..154153 | 63482 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 191 a.a. Molecular weight: 21462.72 Da Isoelectric Point: 6.4027
>T45147 WP_004869854.1 NZ_CP005986:c98985-98413 [Acidithiobacillus caldus ATCC 51756]
MSSHFTVVYDACVLYPAPLRDLLMHLALSDLYRARWSDRIHDEWMRNVLASRPDLTAEQLERTRRLMNAHVRDCLVTGFE
YLIASIELPDPSDRHVVAAAIHAGASLIVTFNLKDFPAEALKPYNLAAQHPDDFIVDLLDLHPAGVLEAVARHRRNLKNP
PKSADDYLDTLLAQGLTQSVAVMRPWVMAM
MSSHFTVVYDACVLYPAPLRDLLMHLALSDLYRARWSDRIHDEWMRNVLASRPDLTAEQLERTRRLMNAHVRDCLVTGFE
YLIASIELPDPSDRHVVAAAIHAGASLIVTFNLKDFPAEALKPYNLAAQHPDDFIVDLLDLHPAGVLEAVARHRRNLKNP
PKSADDYLDTLLAQGLTQSVAVMRPWVMAM
Download Length: 573 bp
>T45147 NZ_CP005986:c98985-98413 [Acidithiobacillus caldus ATCC 51756]
ATGAGCTCGCACTTCACCGTCGTCTACGACGCCTGCGTGCTCTATCCCGCGCCCCTGCGCGATCTGTTGATGCATCTGGC
GCTGTCGGACCTGTACCGGGCGCGCTGGAGCGACAGGATTCACGACGAGTGGATGCGCAACGTGCTGGCCAGCCGTCCCG
ATCTGACTGCCGAGCAACTCGAGCGCACGCGGCGGCTGATGAACGCCCACGTCCGCGACTGCCTGGTCACCGGCTTCGAG
TACCTGATTGCCTCGATCGAGTTGCCCGACCCCAGCGACCGCCATGTGGTGGCGGCCGCCATCCACGCCGGCGCCAGCCT
CATCGTGACCTTCAACCTCAAGGACTTCCCCGCTGAGGCGCTCAAGCCCTACAACCTCGCGGCGCAGCATCCGGACGACT
TCATCGTCGATCTGCTGGATCTGCACCCGGCCGGCGTGCTCGAAGCAGTCGCCCGCCACCGCCGCAATCTGAAGAACCCG
CCCAAGTCGGCGGACGACTACCTGGACACCCTGCTGGCGCAGGGGCTGACGCAATCGGTGGCGGTGATGCGCCCATGGGT
CATGGCCATGTGA
ATGAGCTCGCACTTCACCGTCGTCTACGACGCCTGCGTGCTCTATCCCGCGCCCCTGCGCGATCTGTTGATGCATCTGGC
GCTGTCGGACCTGTACCGGGCGCGCTGGAGCGACAGGATTCACGACGAGTGGATGCGCAACGTGCTGGCCAGCCGTCCCG
ATCTGACTGCCGAGCAACTCGAGCGCACGCGGCGGCTGATGAACGCCCACGTCCGCGACTGCCTGGTCACCGGCTTCGAG
TACCTGATTGCCTCGATCGAGTTGCCCGACCCCAGCGACCGCCATGTGGTGGCGGCCGCCATCCACGCCGGCGCCAGCCT
CATCGTGACCTTCAACCTCAAGGACTTCCCCGCTGAGGCGCTCAAGCCCTACAACCTCGCGGCGCAGCATCCGGACGACT
TCATCGTCGATCTGCTGGATCTGCACCCGGCCGGCGTGCTCGAAGCAGTCGCCCGCCACCGCCGCAATCTGAAGAACCCG
CCCAAGTCGGCGGACGACTACCTGGACACCCTGCTGGCGCAGGGGCTGACGCAATCGGTGGCGGTGATGCGCCCATGGGT
CATGGCCATGTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 16917.33 Da Isoelectric Point: 6.3359
>AT45147 WP_004869856.1 NZ_CP005986:c99451-98990 [Acidithiobacillus caldus ATCC 51756]
MTTPTIPNALPSAEDVALARESGRVLSTVLQTRAETQQIDFHDDKGAVRSVTLPTTALRLLLDVLTEIGQGNAVTVIPIH
AELTTQEAADLLNVSRPFLVQLLEKGEIPFHKIGTHRRVRYQDVIAYKHRIDAERRKALDELAAQAQELGMGY
MTTPTIPNALPSAEDVALARESGRVLSTVLQTRAETQQIDFHDDKGAVRSVTLPTTALRLLLDVLTEIGQGNAVTVIPIH
AELTTQEAADLLNVSRPFLVQLLEKGEIPFHKIGTHRRVRYQDVIAYKHRIDAERRKALDELAAQAQELGMGY
Download Length: 462 bp
>AT45147 NZ_CP005986:c99451-98990 [Acidithiobacillus caldus ATCC 51756]
ATGACGACCCCCACCATCCCCAATGCGCTGCCCTCGGCCGAGGACGTCGCGCTGGCTCGGGAATCCGGGCGCGTGCTCTC
GACGGTGCTGCAAACGCGCGCCGAGACCCAGCAGATCGACTTCCACGACGACAAGGGCGCCGTGCGCTCAGTGACGCTGC
CGACGACGGCGCTGCGGTTGCTGCTGGACGTGCTGACCGAGATCGGCCAGGGCAATGCCGTCACCGTCATCCCCATCCAC
GCCGAACTGACCACGCAGGAAGCGGCCGACCTGCTCAACGTCTCGCGGCCCTTCCTCGTGCAGTTGCTGGAAAAAGGCGA
GATCCCGTTCCACAAGATCGGCACGCATCGTCGGGTGCGTTACCAGGACGTGATCGCCTACAAGCACCGGATCGATGCCG
AGCGCCGCAAGGCCCTCGACGAACTGGCCGCGCAGGCCCAGGAACTCGGCATGGGGTACTGA
ATGACGACCCCCACCATCCCCAATGCGCTGCCCTCGGCCGAGGACGTCGCGCTGGCTCGGGAATCCGGGCGCGTGCTCTC
GACGGTGCTGCAAACGCGCGCCGAGACCCAGCAGATCGACTTCCACGACGACAAGGGCGCCGTGCGCTCAGTGACGCTGC
CGACGACGGCGCTGCGGTTGCTGCTGGACGTGCTGACCGAGATCGGCCAGGGCAATGCCGTCACCGTCATCCCCATCCAC
GCCGAACTGACCACGCAGGAAGCGGCCGACCTGCTCAACGTCTCGCGGCCCTTCCTCGTGCAGTTGCTGGAAAAAGGCGA
GATCCCGTTCCACAAGATCGGCACGCATCGTCGGGTGCGTTACCAGGACGTGATCGCCTACAAGCACCGGATCGATGCCG
AGCGCCGCAAGGCCCTCGACGAACTGGCCGCGCAGGCCCAGGAACTCGGCATGGGGTACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|