Detailed information of TA system TA045144

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 978060..978866
• Replicon: chromosome
• Accession: NZ_CP005973
• Organism: Photobacterium gaetbulicola Gung47

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C5WLA1
• Locus tag: H744_RS04115
• Protein ID: WP_044621084.1
• Coordinates: 978060..978596 (-)
• Length: 179 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H744_RS04120
• Protein ID: WP_044621903.1
• Coordinates: 978597..978866 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H744_RS04080	973486..973701	+	216	WP_044621077.1	YnbE family lipoprotein	-
H744_RS04085	973720..974043	+	324	WP_044621078.1	YdbL family protein	-
H744_RS04090	974196..975146	+	951	WP_044621079.1	putative sulfate exporter family transporter	-
H744_RS04095	975222..975473	-	252	WP_146149068.1	hypothetical protein	-
H744_RS04100	975583..976884	-	1302	WP_044621081.1	Y-family DNA polymerase	-
H744_RS04105	976888..977271	-	384	WP_044621082.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
H744_RS04110	977605..978015	+	411	WP_044621083.1	SPOR domain-containing protein	-
H744_RS04115	978060..978596	-	537	WP_044621084.1	GNAT family N-acetyltransferase	Toxin
H744_RS04120	978597..978866	-	270	WP_044621903.1	DUF1778 domain-containing protein	Antitoxin
H744_RS04125	978989..980365	-	1377	WP_044621085.1	MATE family efflux transporter	-
H744_RS04130	980622..981584	+	963	WP_044621086.1	LysR family transcriptional regulator	-
H744_RS04135	981612..982541	-	930	WP_044621087.1	FAD-binding protein	-
H744_RS04140	982541..983314	-	774	WP_044621088.1	electron transfer flavoprotein subunit beta/FixA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-80)

Sequences

Toxin

Protein

• Length: 179 a.a.
• Molecular weight: 20094.55 Da
• Isoelectric Point: 9.1446

>T45144 WP_044621084.1 NZ_CP005973:c978596-978060 [Photobacterium gaetbulicola Gung47]
VSWAKEFIELDKKLHDRASFDCGEPELNTFIQTQAAKHMQAGISRTMVLPALLPLPNQKRPICAFYSIAPSSICRDTLPA
AMAKKLPKYPIPVFLLAQLAVHHEYHGNGLGKVSLVKALRYLWQVNAHMRAYAIVVDCLSSEAESFYTKYGFEVLCEHNG
RVRMFIPMKTVGQLFEGR

Nucleotide

• Length: 537 bp

>T45144 NZ_CP005973:c978596-978060 [Photobacterium gaetbulicola Gung47]
GTGAGTTGGGCCAAAGAGTTTATCGAGCTTGATAAAAAGCTGCATGACCGCGCGTCCTTTGACTGCGGTGAACCGGAACT
AAATACCTTCATTCAGACTCAGGCGGCAAAACATATGCAGGCAGGTATCAGCCGTACCATGGTGCTACCTGCCTTACTTC
CTCTACCCAATCAAAAACGGCCCATTTGTGCGTTCTATAGCATTGCGCCGAGCTCGATTTGTCGCGATACATTACCGGCG
GCAATGGCTAAAAAGCTTCCCAAGTATCCGATTCCTGTTTTTTTGCTTGCTCAACTTGCCGTTCACCACGAATATCATGG
CAATGGACTGGGTAAAGTGAGTTTAGTCAAGGCATTGAGATATCTTTGGCAAGTCAATGCTCATATGAGGGCGTATGCGA
TTGTCGTTGATTGTCTGAGCTCCGAAGCGGAATCCTTTTATACCAAATATGGCTTTGAAGTGCTTTGCGAGCACAACGGG
CGGGTACGGATGTTTATACCGATGAAAACTGTCGGCCAGTTGTTTGAAGGGCGATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9802.12 Da
• Isoelectric Point: 4.4398

>AT45144 WP_044621903.1 NZ_CP005973:c978866-978597 [Photobacterium gaetbulicola Gung47]
MATARLDLRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDASQVIAQHESITVDGDVFDRFVDACDKAKSPNKALLDAV
DFADEKGFK

Nucleotide

• Length: 270 bp

>AT45144 NZ_CP005973:c978866-978597 [Photobacterium gaetbulicola Gung47]
ATGGCAACAGCACGTTTGGACTTGCGCCTGGATGAAGAAATTAAAGCCAAAGCTGAAAAGGCCTCGGCACTTTTGGGGCT
GAAAAGTTTGACTGAGTACGTGGTCCGTCTGATGGATGAAGATGCCAGCCAGGTAATCGCTCAGCATGAAAGCATCACTG
TTGATGGTGATGTATTTGATCGGTTCGTTGATGCTTGCGATAAGGCTAAATCACCGAATAAAGCTTTGCTCGATGCTGTG
GATTTTGCAGATGAAAAGGGCTTTAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0C5WLA1