Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 165737..166113 Replicon plasmid p1ColV5155
Accession NZ_CP005931
Organism Escherichia coli APEC IMT5155

Toxin (Protein)


Gene name parE Uniprot ID A0A075MDK3
Locus tag L282_RS25720 Protein ID WP_000969988.1
Coordinates 165737..165919 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag L282_RS25725 Protein ID WP_001324224.1
Coordinates 165916..166113 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L282_RS25690 161986..162333 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
L282_RS25695 162333..163010 - 678 WP_001339397.1 IS66 family insertion sequence hypothetical protein -
L282_RS25705 163736..164770 - 1035 WP_001190233.1 3-deoxy-7-phosphoheptulonate synthase -
L282_RS25715 165330..165638 - 309 WP_000377483.1 hypothetical protein -
L282_RS25720 165737..165919 - 183 WP_000969988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L282_RS25725 165916..166113 - 198 WP_001324224.1 toxin-antitoxin system protein Antitoxin
L282_RS25730 166795..168069 + 1275 WP_000489608.1 HlyD family secretion protein -
L282_RS25735 168044..170158 + 2115 WP_001183604.1 peptidase domain-containing ABC transporter -
L282_RS25740 170328..170639 - 312 WP_001259758.1 colicin V -
L282_RS29290 170617..170853 - 237 WP_001323890.1 colicin V immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / vat 1..194170 194170


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6931.07 Da        Isoelectric Point: 4.5349

>T45136 WP_000969988.1 NZ_CP005931:c165919-165737 [Escherichia coli APEC IMT5155]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Download         Length: 183 bp

>T45136 NZ_CP005931:c165919-165737 [Escherichia coli APEC IMT5155]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7658.53 Da        Isoelectric Point: 7.2046

>AT45136 WP_001324224.1 NZ_CP005931:c166113-165916 [Escherichia coli APEC IMT5155]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Download         Length: 198 bp

>AT45136 NZ_CP005931:c166113-165916 [Escherichia coli APEC IMT5155]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075MDK3

Antitoxin

Source ID Structure

References