Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2969093..2969451 Replicon chromosome
Accession NZ_CP005930
Organism Escherichia coli APEC IMT5155

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag L282_RS29475 Protein ID WP_001332330.1
Coordinates 2969329..2969451 (+) Length 41 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag L282_RS14730 Protein ID WP_000125566.1
Coordinates 2969093..2969326 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L282_RS14705 2964166..2964453 + 288 WP_000203741.1 ferredoxin-like protein FixX -
L282_RS14710 2964512..2965843 + 1332 WP_001183207.1 MFS transporter -
L282_RS14715 2965951..2966481 + 531 WP_000600749.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
L282_RS14720 2966474..2968336 + 1863 WP_000377122.1 glutathione-regulated potassium-efflux system protein KefC -
L282_RS14725 2968528..2969007 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
L282_RS14730 2969093..2969326 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
L282_RS29475 2969329..2969451 + 123 WP_001332330.1 CcdB family protein Toxin
L282_RS29480 2969492..2969644 + 153 WP_146692624.1 CcdB family protein -
L282_RS14740 2969641..2970489 - 849 WP_000257201.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
L282_RS14745 2970496..2970873 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
L282_RS14750 2970876..2971697 - 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
L282_RS14755 2971694..2972683 - 990 WP_000241229.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
L282_RS14760 2972683..2973969 - 1287 WP_039267775.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-39)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4563.34 Da        Isoelectric Point: 10.9266

>T45112 WP_001332330.1 NZ_CP005930:2969329-2969451 [Escherichia coli APEC IMT5155]
MQFTVYRSRGRNAAFPFVIDVTSDIVGEINRRIVIPLTPI

Download         Length: 123 bp

>T45112 NZ_CP005930:2969329-2969451 [Escherichia coli APEC IMT5155]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTGTTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT45112 WP_000125566.1 NZ_CP005930:2969093-2969326 [Escherichia coli APEC IMT5155]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT45112 NZ_CP005930:2969093-2969326 [Escherichia coli APEC IMT5155]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References