Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 109708..110539 Replicon chromosome
Accession NZ_CP005930
Organism Escherichia coli APEC IMT5155

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag L282_RS00630 Protein ID WP_000854814.1
Coordinates 110165..110539 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag L282_RS00625 Protein ID WP_001285585.1
Coordinates 109708..110076 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L282_RS00590 106065..106412 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
L282_RS00595 106412..107089 - 678 WP_001339397.1 IS66 family insertion sequence hypothetical protein -
L282_RS28725 107147..107379 + 233 Protein_92 DUF905 family protein -
L282_RS00605 107479..108297 + 819 WP_001234629.1 DUF945 domain-containing protein -
L282_RS00610 108379..108858 + 480 WP_000860087.1 antirestriction protein -
L282_RS00615 108874..109350 + 477 WP_039267628.1 RadC family protein -
L282_RS00620 109413..109634 + 222 WP_000692323.1 DUF987 domain-containing protein -
L282_RS00625 109708..110076 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
L282_RS00630 110165..110539 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
L282_RS00635 110536..110730 + 195 WP_000988600.1 hypothetical protein -
L282_RS29410 110743..110856 + 114 WP_001161660.1 DUF957 domain-containing protein -
L282_RS26190 111145..111273 - 129 Protein_101 transposase domain-containing protein -
L282_RS00645 111345..111527 + 183 WP_001016348.1 hypothetical protein -
L282_RS00650 111628..111957 - 330 WP_039267629.1 DUF496 family protein -
L282_RS00655 112129..113187 - 1059 WP_001200891.1 FUSC family protein -
L282_RS00660 113385..113858 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
L282_RS00665 113977..115143 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T45103 WP_000854814.1 NZ_CP005930:110165-110539 [Escherichia coli APEC IMT5155]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T45103 NZ_CP005930:110165-110539 [Escherichia coli APEC IMT5155]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT45103 WP_001285585.1 NZ_CP005930:109708-110076 [Escherichia coli APEC IMT5155]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT45103 NZ_CP005930:109708-110076 [Escherichia coli APEC IMT5155]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References