Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 5051235..5051856 Replicon chromosome
Accession NZ_CP005927
Organism Serratia sp. FS14

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag L085_RS23155 Protein ID WP_004940313.1
Coordinates 5051653..5051856 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag L085_RS23150 Protein ID WP_004940312.1
Coordinates 5051235..5051603 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L085_RS23120 5047334..5047588 + 255 WP_004940303.1 type B 50S ribosomal protein L31 -
L085_RS23125 5047601..5047741 + 141 WP_004940304.1 type B 50S ribosomal protein L36 -
L085_RS23130 5047849..5048727 - 879 WP_044031826.1 metal ABC transporter substrate-binding protein -
L085_RS23135 5048753..5049610 - 858 WP_044031827.1 metal ABC transporter permease -
L085_RS23140 5049607..5050320 - 714 WP_044031828.1 ABC transporter ATP-binding protein -
L085_RS23145 5050723..5051076 + 354 WP_004940311.1 hypothetical protein -
L085_RS23150 5051235..5051603 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
L085_RS23155 5051653..5051856 + 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
L085_RS23160 5052439..5052753 + 315 WP_015376856.1 MGMT family protein -
L085_RS23165 5052818..5053309 - 492 WP_015376855.1 YbaY family lipoprotein -
L085_RS23170 5053541..5054404 + 864 WP_015376854.1 acyl-CoA thioesterase II -
L085_RS23175 5054495..5055781 - 1287 WP_004940322.1 ammonium transporter AmtB -
L085_RS23180 5055818..5056156 - 339 WP_004940327.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T45102 WP_004940313.1 NZ_CP005927:5051653-5051856 [Serratia sp. FS14]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T45102 NZ_CP005927:5051653-5051856 [Serratia sp. FS14]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCAGATCATCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT45102 WP_004940312.1 NZ_CP005927:5051235-5051603 [Serratia sp. FS14]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT45102 NZ_CP005927:5051235-5051603 [Serratia sp. FS14]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References