Detailed information of TA system TA045101

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 4930736..4931501
• Replicon: chromosome
• Accession: NZ_CP005927
• Organism: Serratia sp. FS14

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: L085_RS22650
• Protein ID: WP_044031780.1
• Coordinates: 4930736..4931104 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: L085_RS24930
• Protein ID: WP_071841655.1
• Coordinates: 4931163..4931501 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L085_RS22630	4925910..4926974	+	1065	WP_044031777.1	aldo/keto reductase	-
L085_RS22635	4927155..4928687	-	1533	WP_044031778.1	glycosyltransferase family 39 protein	-
L085_RS25645	4928813..4928956	-	144	WP_015376917.1	hypothetical protein	-
L085_RS22640	4929314..4929625	+	312	WP_044031779.1	hypothetical protein	-
L085_RS24925	4929746..4929941	+	196	Protein_4519	tyrosine-type recombinase/integrase	-
L085_RS25525	4930144..4930305	-	162	WP_158499089.1	hypothetical protein	-
L085_RS22645	4930410..4930739	-	330	WP_049870699.1	hypothetical protein	-
L085_RS22650	4930736..4931104	-	369	WP_044031780.1	TA system toxin CbtA family protein	Toxin
L085_RS24930	4931163..4931501	-	339	WP_071841655.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
L085_RS22655	4931530..4932009	-	480	WP_044032126.1	DNA repair protein RadC	-
L085_RS22660	4932037..4932495	-	459	WP_071841656.1	antirestriction protein	-
L085_RS22665	4932807..4933283	-	477	WP_049870700.1	hypothetical protein	-
L085_RS22670	4933365..4933712	-	348	WP_044031781.1	hypothetical protein	-
L085_RS22675	4934484..4935335	-	852	WP_044031782.1	hypothetical protein	-
L085_RS25470	4935334..4935540	+	207	WP_144240709.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4930736..4942471	11735

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-110)

Antitoxin

• Antitoxin CbeA (8-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13371.32 Da
• Isoelectric Point: 8.2858

>T45101 WP_044031780.1 NZ_CP005927:c4931104-4930736 [Serratia sp. FS14]
MRTLHAPPSRAAQTCQSPITVWQSLLTYLLAQHYGLTLNDTAFSDDAVIQAHIGDGISLADALNAMVEKFDLVRIDRRGF
SCEAQSPLVTAIDILRARRACGLMTRAGYQDVTRTIQGGKRP

Nucleotide

• Length: 369 bp

>T45101 NZ_CP005927:c4931104-4930736 [Serratia sp. FS14]
ATGCGAACACTACACGCGCCACCCTCACGGGCGGCCCAAACATGCCAGTCCCCCATCACTGTCTGGCAATCCTTGCTCAC
CTACCTGCTGGCGCAGCACTATGGCCTGACACTCAACGACACCGCATTCAGCGACGATGCCGTAATACAGGCCCATATCG
GTGACGGTATATCCCTCGCGGATGCGCTGAATGCCATGGTGGAAAAGTTTGATCTGGTACGCATTGACCGCCGGGGCTTC
AGCTGTGAGGCTCAATCGCCCCTCGTGACCGCCATAGATATTCTACGTGCCCGCCGGGCCTGCGGCCTGATGACGCGAGC
CGGTTACCAGGATGTCACACGAACGATTCAGGGAGGCAAGCGCCCATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12710.45 Da
• Isoelectric Point: 7.0375

>AT45101 WP_071841655.1 NZ_CP005927:c4931501-4931163 [Serratia sp. FS14]
MPSPHNVPAWGLKRNVTPQFGARLVQEGERLHFLADRADIGGIFSDAQRRDLENAFPRFIKHLELMLLSGELNPRHQHCV
TLYCHGLTCEADSLGSYGYVYISIYPTTETPR

Nucleotide

• Length: 339 bp

>AT45101 NZ_CP005927:c4931501-4931163 [Serratia sp. FS14]
ATGCCATCACCCCATAATGTTCCCGCCTGGGGACTAAAACGTAATGTCACGCCGCAGTTTGGCGCCCGTTTGGTACAGGA
GGGGGAACGACTGCATTTTCTGGCCGACCGCGCTGACATCGGCGGAATTTTCAGCGACGCCCAGCGCCGTGACTTGGAGA
ATGCTTTTCCGCGATTTATCAAGCATCTGGAATTGATGCTGCTATCTGGCGAGCTCAATCCGCGCCATCAGCACTGTGTC
ACGCTGTATTGCCATGGCCTGACCTGTGAAGCAGACAGCCTCGGCTCATACGGCTACGTCTACATTTCGATTTATCCGAC
AACTGAAACGCCCAGGTAA