Detailed information of TA system TA045100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 4531290..4531843
• Replicon: chromosome
• Accession: NZ_CP005927
• Organism: Serratia sp. FS14

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A1Q5WDY9
• Locus tag: L085_RS20660
• Protein ID: WP_015377213.1
• Coordinates: 4531290..4531604 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: L085_RS20665
• Protein ID: WP_044031607.1
• Coordinates: 4531607..4531843 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L085_RS20640	4527059..4528216	-	1158	WP_044032108.1	YbfB/YjiJ family MFS transporter	-
L085_RS20645	4528322..4529242	+	921	WP_004938975.1	LysR family transcriptional regulator	-
L085_RS20650	4529272..4530396	+	1125	WP_044031606.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
L085_RS20655	4530411..4531253	+	843	WP_015377214.1	S-formylglutathione hydrolase	-
L085_RS20660	4531290..4531604	-	315	WP_015377213.1	CcdB family protein	Toxin
L085_RS20665	4531607..4531843	-	237	WP_044031607.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
L085_RS20670	4531951..4532859	-	909	WP_193378773.1	glutathione ABC transporter permease GsiD	-
L085_RS20675	4532869..4533789	-	921	WP_004938995.1	glutathione ABC transporter permease GsiC	-
L085_RS20680	4533842..4535377	-	1536	WP_004938996.1	glutathione ABC transporter substrate-binding protein GsiB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11662.55 Da
• Isoelectric Point: 4.7085

>T45100 WP_015377213.1 NZ_CP005927:c4531604-4531290 [Serratia sp. FS14]
MQFTVYANSGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRSRIKAAIDFLLDGI

Nucleotide

• Length: 315 bp

>T45100 NZ_CP005927:c4531604-4531290 [Serratia sp. FS14]
ATGCAATTTACGGTGTATGCGAATAGCGGGAACAGCGCGGTTTACCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGCCGAGTTGTGATCCCTTTGTTGCCCGTTGAAAAATACCCGGGGAGTACGCGACCGGAGCGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAATTTTGTGATGTTTCCCAGTATCGGAGCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9153.21 Da
• Isoelectric Point: 6.4641

>AT45100 WP_044031607.1 NZ_CP005927:c4531843-4531607 [Serratia sp. FS14]
MPVKQRTTQSVTMTLERSLLSRAREVGINLSATLTAALDAELRQHERRKWQEENREALEALNRFNDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT45100 NZ_CP005927:c4531843-4531607 [Serratia sp. FS14]
ATGCCAGTAAAACAACGAACGACGCAAAGTGTGACCATGACGCTGGAACGCAGTTTGTTGAGCCGTGCGCGTGAGGTGGG
GATTAATCTCAGCGCGACGCTGACTGCTGCTTTAGATGCTGAGTTGCGTCAGCATGAGAGGAGAAAATGGCAGGAAGAAA
ACCGAGAGGCACTTGAAGCGCTTAACCGATTTAATGATGAGCATGGTTGCTTTAGCGACGAATACAGGACGTTTTAG

Structures

Toxin

• AlphaFold DB: A0A1Q5WDY9