Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2376459..2377021 Replicon chromosome
Accession NZ_CP005927
Organism Serratia sp. FS14

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag L085_RS10750 Protein ID WP_044030725.1
Coordinates 2376665..2377021 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag L085_RS10745 Protein ID WP_004936539.1
Coordinates 2376459..2376668 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L085_RS10720 2372608..2372934 + 327 WP_033643982.1 phage holin, lambda family -
L085_RS10725 2372924..2373325 + 402 WP_033643981.1 M15 family metallopeptidase -
L085_RS10730 2373322..2373702 + 381 WP_044030723.1 DUF2570 family protein -
L085_RS25585 2373683..2373856 + 174 WP_021505636.1 hypothetical protein -
L085_RS10740 2374070..2376349 + 2280 WP_044030724.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
L085_RS10745 2376459..2376668 + 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L085_RS10750 2376665..2377021 + 357 WP_044030725.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
L085_RS10755 2377031..2377969 - 939 WP_044030726.1 homocysteine S-methyltransferase -
L085_RS10760 2377959..2379368 - 1410 WP_044030727.1 S-methylmethionine permease -
L085_RS10765 2379546..2380385 + 840 WP_044030728.1 ChaN family lipoprotein -
L085_RS10770 2380488..2381285 + 798 WP_044030729.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13154.92 Da        Isoelectric Point: 4.7274

>T45090 WP_044030725.1 NZ_CP005927:2376665-2377021 [Serratia sp. FS14]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEQLRRLTE

Download         Length: 357 bp

>T45090 NZ_CP005927:2376665-2377021 [Serratia sp. FS14]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAACGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTATACCGCTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCGGAGCAACTGCGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT45090 WP_004936539.1 NZ_CP005927:2376459-2376668 [Serratia sp. FS14]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT45090 NZ_CP005927:2376459-2376668 [Serratia sp. FS14]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCCAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References