Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2266739..2267395 Replicon chromosome
Accession NZ_CP005927
Organism Serratia sp. FS14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L085_RS10265 Protein ID WP_021504433.1
Coordinates 2267006..2267395 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag L085_RS10260 Protein ID WP_004941563.1
Coordinates 2266739..2267002 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L085_RS10240 2261849..2262898 - 1050 WP_015378749.1 class I fructose-bisphosphate aldolase -
L085_RS10245 2263159..2264064 - 906 WP_044030681.1 lipid kinase YegS -
L085_RS10250 2264532..2265884 - 1353 WP_004941558.1 tRNA 5-hydroxyuridine modification protein YegQ -
L085_RS10255 2266063..2266401 - 339 WP_004941561.1 YegP family protein -
L085_RS10260 2266739..2267002 + 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L085_RS10265 2267006..2267395 + 390 WP_021504433.1 type II toxin-antitoxin system VapC family toxin Toxin
L085_RS10270 2267403..2268119 - 717 WP_015378739.1 two-component system response regulator BaeR -
L085_RS10275 2268119..2269502 - 1384 Protein_2034 two-component system sensor histidine kinase BaeS -
L085_RS10280 2269499..2270929 - 1431 WP_044030682.1 multidrug transporter subunit MdtD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14398.63 Da        Isoelectric Point: 8.4983

>T45089 WP_021504433.1 NZ_CP005927:2267006-2267395 [Serratia sp. FS14]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T45089 NZ_CP005927:2267006-2267395 [Serratia sp. FS14]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTTCGTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGAGAGAAAGGGCAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT45089 WP_004941563.1 NZ_CP005927:2266739-2267002 [Serratia sp. FS14]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT45089 NZ_CP005927:2266739-2267002 [Serratia sp. FS14]
ATGGAAAGGATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCCGACCGC
GATCCCTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References