Detailed information of TA system TA045085

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1083935..1084702
• Replicon: chromosome
• Accession: NZ_CP005927
• Organism: Serratia sp. FS14

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: L085_RS05000
• Protein ID: WP_025160422.1
• Coordinates: 1084334..1084702 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: L085_RS04995
• Protein ID: WP_044030218.1
• Coordinates: 1083935..1084270 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L085_RS04970	1080043..1080849	+	807	WP_044030214.1	hypothetical protein	-
L085_RS04975	1081058..1081813	+	756	WP_044031930.1	50S ribosome-binding GTPase	-
L085_RS04980	1082061..1082615	+	555	WP_044030216.1	hypothetical protein	-
L085_RS04985	1082643..1083263	+	621	WP_044031931.1	hypothetical protein	-
L085_RS24375	1083446..1083925	+	480	WP_071841599.1	DNA repair protein RadC	-
L085_RS04995	1083935..1084270	+	336	WP_044030218.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
L085_RS05000	1084334..1084702	+	369	WP_025160422.1	TA system toxin CbtA family protein	Toxin
L085_RS05005	1084932..1085786	+	855	WP_044031932.1	DUF4942 domain-containing protein	-
L085_RS05010	1086135..1086473	-	339	WP_044030221.1	hypothetical protein	-
L085_RS05015	1086673..1087575	-	903	WP_044030222.1	LysR family transcriptional regulator	-
L085_RS05020	1087716..1089251	+	1536	WP_044030224.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13713.73 Da
• Isoelectric Point: 5.5998

>T45085 WP_025160422.1 NZ_CP005927:1084334-1084702 [Serratia sp. FS14]
MQILPVTPKQAAYACPSPVIVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTITSVIRGEKQT

Nucleotide

• Length: 369 bp

>T45085 NZ_CP005927:1084334-1084702 [Serratia sp. FS14]
ATGCAAATCTTACCTGTCACTCCGAAACAGGCGGCTTACGCTTGCCCATCACCCGTTATTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCGCTTAACGATACCGAGTTCAGTGATGACGCGGTGATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGTTGAATTTCACGGTGGAAAAGTTCGACCTGGTTCGCATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGCGAAAAGCAGACATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12388.06 Da
• Isoelectric Point: 6.0536

>AT45085 WP_044030218.1 NZ_CP005927:1083935-1084270 [Serratia sp. FS14]
MPPIIAPAWGLKRNVTPQLGARLVQEGDRLHFLIDRADISGTFSDAQLRDVDNTFPQFINHLELMLLSGELNPRYQHCVT
LYRNGLTCEADSLGSHGYVYLSIYPTPSSTA

Nucleotide

• Length: 336 bp

>AT45085 NZ_CP005927:1083935-1084270 [Serratia sp. FS14]
ATGCCACCAATCATTGCCCCGGCCTGGGGACTCAAACGCAACGTCACTCCGCAGTTGGGTGCCCGCCTGGTACAGGAAGG
TGACCGGCTGCATTTTCTGATCGACCGTGCCGATATCAGCGGGACCTTCAGCGACGCGCAGCTACGAGATGTAGATAACA
CTTTCCCGCAGTTCATCAACCACCTGGAACTGATGCTGCTTTCTGGTGAACTCAATCCCCGCTATCAGCACTGCGTCACG
CTTTACCGCAATGGACTAACCTGTGAAGCCGATAGCCTGGGATCACACGGCTATGTGTATCTCTCCATTTATCCTACGCC
TTCATCAACGGCATAA