Detailed information of TA system TA045084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 665735..666471
• Replicon: chromosome
• Accession: NZ_CP005927
• Organism: Serratia sp. FS14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L085_RS03145
• Protein ID: WP_044030011.1
• Coordinates: 665992..666471 (+)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5C7DAD3
• Locus tag: L085_RS03140
• Protein ID: WP_015379309.1
• Coordinates: 665735..665995 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L085_RS03120	661807..662487	+	681	WP_004930298.1	GMP/IMP nucleotidase	-
L085_RS03125	662484..662891	+	408	WP_015379306.1	ribosome-associated heat shock protein Hsp15	-
L085_RS03130	662917..663795	+	879	WP_015379307.1	Hsp33 family molecular chaperone HslO	-
L085_RS03135	663990..665609	+	1620	WP_044030010.1	phosphoenolpyruvate carboxykinase (ATP)	-
L085_RS03140	665735..665995	+	261	WP_015379309.1	plasmid stability-like protein	Antitoxin
L085_RS03145	665992..666471	+	480	WP_044030011.1	type II toxin-antitoxin system VapC family toxin	Toxin
L085_RS03150	666504..667874	-	1371	WP_031300055.1	two-component system sensor histidine kinase EnvZ	-
L085_RS03155	667871..668590	-	720	WP_004709363.1	two-component system response regulator OmpR	-
L085_RS03160	668847..669152	-	306	WP_004930739.1	chaperone-modulator protein CbpM	-
L085_RS03165	669158..670120	-	963	WP_004930742.1	curved DNA-binding protein	-
L085_RS03170	670350..670823	+	474	WP_004930745.1	transcription elongation factor GreB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17997.65 Da
• Isoelectric Point: 6.2154

>T45084 WP_044030011.1 NZ_CP005927:665992-666471 [Serratia sp. FS14]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGANRRRGIGVSMPDTQIAATCLHYGAALATRNTKNFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T45084 NZ_CP005927:665992-666471 [Serratia sp. FS14]
ATGATTGTGCTGGATACCAACGTCGTTTCGGAATTGCTGCGGCCGGCGCCTCACTACAATGTATTGCGCTGGTTAGATGA
GCAGGATACGTATCGGTTCTATTTGAGCGCCATCGTGGTTGCGGAGTTGTATACGGGCATCGCCTGCATGCCTCACGGCA
AGAAACAGCTCGAACTGCAAACTAACCTCGGCGACATGCTGCAGGAAGAGTTTTCAGACAGAATCTTACCCTTTGACGTC
GGCTGTGCGATGCAGCATGCGGAATTAATGGGCGCCAATCGCCGCCGAGGTATTGGCGTCAGCATGCCCGATACCCAAAT
CGCCGCCACCTGCCTGCATTACGGCGCCGCCCTGGCCACCCGCAATACCAAAAACTTCCTCCACTGCGGCATCGAGTTAA
TCGATCCGTGGCAGGCGCCGACCGGCCGTCGGTTGCATGAAGATGCGGCGGAATACTACGTGATGAGCAGAAAGTCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9907.29 Da
• Isoelectric Point: 5.1898

>AT45084 WP_015379309.1 NZ_CP005927:665735-665995 [Serratia sp. FS14]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Nucleotide

• Length: 261 bp

>AT45084 NZ_CP005927:665735-665995 [Serratia sp. FS14]
ATGGCGACTATCACCGTCAGAAATCTGGACGACGAAATCAAAGAACTGCTGCGCATTTCAGCGGCGAAAAACGGCCACTC
CATGGAAGAGGAAGCGCGCATGATCCTGAAGCAGGCGCTGGTGAAAAAGCCGCCGCGCTATGGGTTAGGAACACGCATGC
ATCAGTACTTCGCCGAATTCGGCGGCGTTGAGTTGGAGATCCCCCCACGTGATGAAGCCCCTCATCGTATCGTCAACTTT
GATGAAGATGATGAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DAD3