Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 178562..179121 Replicon plasmid pMI2
Accession NZ_CP005191
Organism Sphingobium sp. MI1205

Toxin (Protein)


Gene name relE Uniprot ID T0H6G6
Locus tag K663_RS21670 Protein ID WP_020819388.1
Coordinates 178828..179121 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T0J1T8
Locus tag K663_RS21665 Protein ID WP_020819389.1
Coordinates 178562..178831 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K663_RS21660 174748..178197 + 3450 WP_020819391.1 YhaN family protein -
K663_RS21665 178562..178831 + 270 WP_020819389.1 ribbon-helix-helix domain-containing protein Antitoxin
K663_RS21670 178828..179121 + 294 WP_020819388.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K663_RS21675 179161..179604 - 444 WP_020819387.1 hypothetical protein -
K663_RS21680 179601..180449 - 849 WP_021224597.1 toprim domain-containing protein -
K663_RS21685 180621..180803 + 183 WP_020819384.1 hypothetical protein -
K663_RS21690 181011..182207 + 1197 WP_015460581.1 AAA family ATPase -
K663_RS21695 182204..183274 + 1071 WP_025160828.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..287488 287488


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11354.99 Da        Isoelectric Point: 7.3579

>T45082 WP_020819388.1 NZ_CP005191:178828-179121 [Sphingobium sp. MI1205]
MKIQWTSKASSDLVRLHEHLGPVAPEAAARVVQQLAHAPDRLIDYPRIGEKLEAYEPREVRRIIVGNYEMRYEIAAGTIF
ILRLWHCRENRNFESEQ

Download         Length: 294 bp

>T45082 NZ_CP005191:178828-179121 [Sphingobium sp. MI1205]
ATGAAGATCCAGTGGACCAGCAAGGCGTCGTCGGACCTTGTGCGACTGCACGAGCATCTGGGTCCGGTCGCCCCCGAAGC
GGCGGCGCGCGTGGTCCAGCAACTCGCCCACGCACCGGATCGGCTGATCGATTATCCGAGGATCGGCGAGAAGCTGGAAG
CCTATGAGCCGCGCGAGGTCCGCCGGATCATCGTCGGCAACTACGAGATGCGCTACGAGATCGCGGCCGGAACGATCTTC
ATACTGCGCCTCTGGCATTGCCGCGAAAACCGCAACTTCGAATCGGAGCAGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9829.20 Da        Isoelectric Point: 5.1312

>AT45082 WP_020819389.1 NZ_CP005191:178562-178831 [Sphingobium sp. MI1205]
MATETKVLTAHVPLGLAEKVEAMASRLERSRGWVVKQALAAWVDQEEERHRMTLEALEDVDAGRVIDHQAITAWADSLGT
DKPLPSPVK

Download         Length: 270 bp

>AT45082 NZ_CP005191:178562-178831 [Sphingobium sp. MI1205]
ATGGCGACCGAGACGAAGGTATTGACCGCGCATGTCCCTCTGGGGCTCGCGGAAAAGGTTGAAGCAATGGCCTCGCGACT
CGAACGCTCGCGCGGCTGGGTGGTGAAGCAAGCGCTCGCCGCCTGGGTCGATCAGGAGGAGGAGCGTCACCGGATGACGC
TCGAAGCCCTGGAGGATGTCGATGCCGGACGGGTGATCGACCACCAGGCGATCACGGCATGGGCCGACAGCCTTGGGACG
GACAAGCCGCTACCCTCGCCGGTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4HNW0

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4HNW7

References