Detailed information of TA system TA045076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 1894443..1894980
• Replicon: chromosome
• Accession: NZ_CP005188
• Organism: Sphingobium sp. MI1205

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: K663_RS09075
• Protein ID: WP_013846902.1
• Coordinates: 1894684..1894980 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: K663_RS09070
• Protein ID: WP_013846901.1
• Coordinates: 1894443..1894694 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K663_RS09040	1889467..1890114	-	648	WP_013846895.1	hypothetical protein	-
K663_RS09045	1890190..1890885	-	696	WP_013846896.1	hypothetical protein	-
K663_RS09050	1891027..1891743	-	717	WP_119034653.1	type I restriction-modification system subunit M	-
K663_RS09055	1892003..1893250	-	1248	WP_013846898.1	hypothetical protein	-
K663_RS09060	1893438..1893743	-	306	WP_013846899.1	hypothetical protein	-
K663_RS09065	1893740..1894216	-	477	WP_013846900.1	hypothetical protein	-
K663_RS09070	1894443..1894694	+	252	WP_013846901.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
K663_RS09075	1894684..1894980	+	297	WP_013846902.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1718305..1912772	194467

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Antitoxin ParD (6-75)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10941.43 Da
• Isoelectric Point: 6.8785

>T45076 WP_013846902.1 NZ_CP005188:1894684-1894980 [Sphingobium sp. MI1205]
MAYRLTRNAEKDLIGIYVGGVGELGEAVAEKYQAGLHRVFGFLSDFPYSARARAEISPPVRAHPYKSHIVVYIIEGQDIL
ILGVRHGREDWQASDQLS

Nucleotide

• Length: 297 bp

>T45076 NZ_CP005188:1894684-1894980 [Sphingobium sp. MI1205]
ATGGCCTATAGACTCACGCGTAACGCCGAAAAGGATCTCATCGGTATATATGTCGGCGGCGTCGGAGAATTAGGAGAAGC
CGTCGCGGAAAAATATCAGGCCGGTTTGCATCGGGTTTTTGGATTTCTCTCCGACTTTCCCTATTCGGCAAGAGCGCGCG
CGGAAATTTCACCACCGGTCCGGGCACATCCCTACAAGTCCCATATCGTCGTCTATATCATCGAAGGACAGGACATCCTG
ATCCTCGGCGTCCGTCATGGACGGGAAGACTGGCAGGCATCCGACCAGCTTTCCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9230.40 Da
• Isoelectric Point: 5.8295

>AT45076 WP_013846901.1 NZ_CP005188:1894443-1894694 [Sphingobium sp. MI1205]
MATMNVSLPDAMKEWVEGQAGTGRYSNASDYVRDLIRRDQERREKIAAMQTMVDESLASGISPNSIDDMMKEARRRAGVG
HGL

Nucleotide

• Length: 252 bp

>AT45076 NZ_CP005188:1894443-1894694 [Sphingobium sp. MI1205]
ATGGCGACAATGAATGTTTCCCTCCCCGATGCGATGAAGGAATGGGTCGAAGGTCAGGCCGGGACAGGCAGATACAGCAA
TGCCAGCGATTATGTGCGCGACCTGATCCGTCGCGACCAGGAGCGGCGGGAGAAGATCGCAGCCATGCAGACCATGGTCG
ATGAGTCTCTCGCCTCCGGCATAAGTCCCAATTCCATCGATGACATGATGAAGGAAGCCCGGCGTCGCGCAGGCGTCGGT
CATGGCCTATAG