45072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 278285..279219 Replicon plasmid pTK1
Accession NZ_CP005085
Organism Sphingobium sp. TKS

Toxin (Protein)


Gene name - Uniprot ID T0GMU6
Locus tag K426_RS26520 Protein ID WP_021243657.1
Coordinates 278285..278803 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A126RVR0
Locus tag K426_RS26525 Protein ID WP_021243658.1
Coordinates 278869..279219 (-) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K426_RS26500 273827..274153 - 327 WP_021243653.1 hypothetical protein -
K426_RS26505 274455..275171 - 717 WP_021243654.1 hypothetical protein -
K426_RS26510 275476..276795 - 1320 WP_031290546.1 SLC13 family permease -
K426_RS26515 276906..277751 + 846 WP_031290547.1 hypothetical protein -
K426_RS26520 278285..278803 - 519 WP_021243657.1 RES family NAD+ phosphorylase Toxin
K426_RS26525 278869..279219 - 351 WP_021243658.1 DUF2384 domain-containing protein Antitoxin
K426_RS30730 279374..279514 + 141 WP_158511792.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..520614 520614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(19-150)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(65-113)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 18027.43 Da        Isoelectric Point: 5.1294

>T45072 WP_021243657.1 NZ_CP005085:c278803-278285 [Sphingobium sp. TKS]
MTYALGQLSLPLWGMIGIRHQFSPTSGEGARLYGGRWNRQGCSALYLAADAVTAVAEYYQGLPKPGTLVPYHLDAGRIAD
LTDAAAGPCDGRVAEALAANWKAVALLDGKTPPNWALTEELIAAGAEGALVPSVQNPGGRNLVLWQWHEKGQQGDGAALT
VLDPDAVLGAPR

Download         Length: 519 bp

>T45072 NZ_CP005085:c278803-278285 [Sphingobium sp. TKS]
ATGACCTATGCTCTTGGCCAGTTGTCGCTTCCCCTCTGGGGCATGATCGGGATCCGCCATCAGTTCAGTCCAACCTCGGG
AGAGGGGGCACGGCTCTACGGCGGCCGCTGGAACAGGCAGGGATGCTCGGCGCTCTATCTGGCGGCGGATGCTGTCACCG
CGGTGGCGGAATATTATCAAGGACTGCCGAAGCCCGGGACGCTCGTCCCTTATCACCTCGATGCGGGGAGAATCGCGGAT
CTCACCGACGCTGCGGCCGGCCCCTGCGATGGGCGCGTTGCTGAAGCCTTGGCGGCGAACTGGAAGGCTGTGGCGTTGCT
CGATGGCAAGACGCCGCCGAACTGGGCGCTAACCGAAGAGCTGATCGCGGCCGGAGCCGAGGGCGCACTTGTTCCCTCGG
TCCAGAATCCTGGCGGCCGGAACCTGGTTCTGTGGCAATGGCACGAGAAGGGGCAGCAAGGCGACGGGGCCGCGCTCACC
GTACTTGATCCTGATGCTGTTCTAGGAGCGCCCCGCTAG

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 12729.68 Da        Isoelectric Point: 6.8819

>AT45072 WP_021243658.1 NZ_CP005085:c279219-278869 [Sphingobium sp. TKS]
MLAAFLDDIREGDMIAPRRMAERLRLPMTRLSRLAHLNRNTMTAHPGSPAVQAKLGEIARIIARAAELAGDEGKAIIWFK
HQPLPGFGKTAEELVEDGHADSVIQDLDRMAAGVYS

Download         Length: 351 bp

>AT45072 NZ_CP005085:c279219-278869 [Sphingobium sp. TKS]
ATGCTTGCTGCTTTTCTGGATGATATTCGCGAGGGTGACATGATCGCCCCACGCCGGATGGCGGAACGCCTGCGGCTTCC
CATGACACGGCTGTCGCGGCTCGCACACCTCAATCGCAACACGATGACAGCGCATCCCGGGAGTCCTGCCGTGCAGGCCA
AGCTGGGAGAGATTGCCCGGATTATCGCGCGCGCAGCCGAGCTGGCAGGGGATGAAGGCAAGGCCATCATCTGGTTCAAG
CACCAGCCGCTCCCCGGATTTGGCAAGACGGCCGAGGAATTGGTTGAGGATGGTCATGCCGATAGCGTGATCCAAGATCT
CGATCGCATGGCCGCCGGTGTCTATTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T0GMU6

Antitoxin

Source ID Structure
AlphaFold DB A0A126RVR0

References