Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 794591..795372 Replicon chromosome
Accession NZ_CP005084
Organism Sphingobium sp. TKS

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A126RU77
Locus tag K426_RS24430 Protein ID WP_066563237.1
Coordinates 794591..795082 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A126RU72
Locus tag K426_RS24435 Protein ID WP_066563239.1
Coordinates 795079..795372 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K426_RS24400 790000..790371 + 372 WP_145907680.1 MarR family transcriptional regulator -
K426_RS24405 790486..791007 - 522 WP_082749195.1 hypothetical protein -
K426_RS32235 791203..791367 + 165 WP_169575789.1 hypothetical protein -
K426_RS24410 791582..792400 + 819 WP_082749152.1 type IV toxin-antitoxin system AbiEi family antitoxin -
K426_RS24415 792387..793307 + 921 WP_066563225.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
K426_RS24420 793410..793943 + 534 WP_140404537.1 hypothetical protein -
K426_RS24425 794046..794528 + 483 WP_066563235.1 hypothetical protein -
K426_RS24430 794591..795082 - 492 WP_066563237.1 GNAT family N-acetyltransferase Toxin
K426_RS24435 795079..795372 - 294 WP_066563239.1 DUF1778 domain-containing protein Antitoxin
K426_RS24440 795986..796552 + 567 WP_082749196.1 RNA polymerase sigma factor -
K426_RS24445 796797..797516 + 720 WP_158511780.1 FecR domain-containing protein -
K426_RS24450 797611..800205 + 2595 WP_066563246.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-142)

Antitoxin

Vibrio phage ICP1, Orf50

(1-96)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17580.21 Da        Isoelectric Point: 7.2925

>T45070 WP_066563237.1 NZ_CP005084:c795082-794591 [Sphingobium sp. TKS]
VTLIAPVPLDDGHLLDEFTSGTASLDDWLRRRARANHESGASRTFVLCDDARVIAYYSLASSSIACAEAVGRFRRNMPDP
IPVITLARLAIDQSIHGKGFGRALIRDAGRRVIAAADLVGVRGMIVHAISDDAKQFYLACGFLQSPTNEMTLMIPLSDLK
AAA

Download         Length: 492 bp

>T45070 NZ_CP005084:c795082-794591 [Sphingobium sp. TKS]
GTGACGCTCATCGCTCCGGTGCCGCTCGATGACGGTCATCTGCTTGACGAATTCACCTCCGGCACGGCTTCGCTTGACGA
TTGGCTAAGGCGCCGCGCGCGTGCCAATCATGAAAGCGGAGCCAGCAGAACTTTCGTCCTGTGCGATGACGCGCGCGTCA
TCGCCTATTATTCGCTGGCCTCCAGTTCGATCGCCTGTGCGGAGGCCGTAGGCCGCTTCCGCCGAAATATGCCAGATCCC
ATTCCGGTTATAACTCTGGCTCGTTTGGCGATCGACCAGTCCATACACGGCAAAGGTTTTGGAAGGGCTCTCATCCGCGA
CGCCGGCCGCCGGGTGATTGCCGCCGCTGACCTTGTCGGCGTCCGTGGCATGATCGTCCATGCAATCAGTGATGACGCGA
AGCAATTTTACTTGGCGTGCGGTTTCCTGCAATCACCCACCAACGAGATGACGCTCATGATCCCGCTTTCCGATTTGAAA
GCGGCTGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10809.24 Da        Isoelectric Point: 8.6855

>AT45070 WP_066563239.1 NZ_CP005084:c795372-795079 [Sphingobium sp. TKS]
MPRTTASSETPLQAVNLRVRKDTQSLIDRAANMLGRTRSDFMIAASRKAAEDAILDQRVISVSSEAYGEFLAMLDRPAQA
NEQLRKTMQTPAPWESQ

Download         Length: 294 bp

>AT45070 NZ_CP005084:c795372-795079 [Sphingobium sp. TKS]
ATGCCACGTACCACCGCCTCCTCGGAAACGCCACTTCAGGCCGTCAATCTGCGTGTTCGAAAGGACACGCAGTCCCTGAT
CGATCGGGCGGCAAACATGCTTGGCCGCACGCGCTCCGACTTCATGATTGCTGCGTCCAGGAAGGCTGCCGAGGATGCCA
TCCTCGACCAACGTGTCATTTCTGTATCGTCCGAAGCCTATGGCGAGTTTTTGGCCATGCTCGACCGCCCCGCGCAAGCG
AATGAGCAGCTTCGCAAAACCATGCAGACGCCCGCGCCCTGGGAGTCCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126RU77

Antitoxin

Source ID Structure
AlphaFold DB A0A126RU72

References