Detailed information of TA system TA045069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3809672..3810474
• Replicon: chromosome
• Accession: NZ_CP005083
• Organism: Sphingobium sp. TKS

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A126RRI7
• Locus tag: K426_RS18850
• Protein ID: WP_030090520.1
• Coordinates: 3809947..3810474 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: -
• Locus tag: K426_RS18845
• Protein ID: WP_030090519.1
• Coordinates: 3809672..3809950 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K426_RS18845	3809672..3809950	+	279	WP_030090519.1	DUF1778 domain-containing protein	Antitoxin
K426_RS18850	3809947..3810474	+	528	WP_030090520.1	hypothetical protein	Toxin
K426_RS18855	3810810..3811151	+	342	WP_021688185.1	sigma-70 family RNA polymerase sigma factor	-
K426_RS18860	3811579..3812799	+	1221	WP_021688184.1	hypothetical protein	-
K426_RS31835	3812809..3812949	+	141	WP_157034366.1	hypothetical protein	-
K426_RS18865	3813023..3813670	+	648	WP_021688183.1	hypothetical protein	-
K426_RS18870	3813682..3814143	+	462	WP_021688182.1	hypothetical protein	-
K426_RS18875	3814187..3814942	+	756	WP_021688181.1	hypothetical protein	-
K426_RS18880	3814948..3815427	+	480	WP_021688180.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (11-88)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19149.84 Da
• Isoelectric Point: 7.9468

>T45069 WP_030090520.1 NZ_CP005083:3809947-3810474 [Sphingobium sp. TKS]
MRLPSWHEDAIAKAHDRASFDCGDNDLNIFLRRYARQSHELGGAKTFLAVDDTDNKTILGFYSIAPGSMDHADTPELARR
GLARHEVPGFRLARLATDIRVQGNGLGGQLLGAIGRRCIRVAAEVGGVMLIIDAKNERAAAWYASYGAITLHDKPLTLIL
PFATLERELRSAGQL

Nucleotide

• Length: 528 bp

>T45069 NZ_CP005083:3809947-3810474 [Sphingobium sp. TKS]
ATGAGACTTCCGTCCTGGCACGAGGACGCGATCGCAAAAGCGCATGACCGAGCTTCCTTCGACTGCGGTGACAATGATCT
GAACATCTTCTTGCGGCGCTATGCCCGGCAAAGCCATGAGCTGGGCGGGGCCAAGACGTTCCTTGCCGTCGACGACACCG
ACAACAAGACGATTCTCGGTTTCTACAGCATCGCTCCTGGCAGCATGGACCATGCCGACACGCCCGAACTTGCGAGGCGG
GGCCTCGCCAGGCATGAAGTGCCCGGTTTCCGGCTCGCGCGGCTTGCAACCGATATTCGGGTGCAGGGGAACGGGCTTGG
GGGGCAACTTCTTGGCGCCATCGGCCGCAGATGCATTCGCGTCGCGGCAGAAGTCGGCGGGGTGATGCTGATCATCGACG
CCAAGAACGAGCGGGCTGCCGCATGGTATGCCAGCTATGGCGCCATAACACTGCACGACAAACCGCTGACCCTCATATTG
CCTTTTGCGACACTTGAACGTGAATTGAGATCAGCGGGTCAATTGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10156.81 Da
• Isoelectric Point: 10.2844

>AT45069 WP_030090519.1 NZ_CP005083:3809672-3809950 [Sphingobium sp. TKS]
MPRAVVEDNRRMSLRIRPEQKALLARAAALRHTDLTTFVTGSALREAESVIEEAERTKLSERDSLLVLDLLENPPPANAK
LRAAIAAMPKLA

Nucleotide

• Length: 279 bp

>AT45069 NZ_CP005083:3809672-3809950 [Sphingobium sp. TKS]
ATGCCGCGAGCTGTGGTGGAAGACAATAGGCGCATGAGCCTGCGCATACGACCGGAGCAAAAGGCTTTGCTCGCCCGGGC
GGCGGCGCTCAGACATACCGATCTGACGACCTTTGTCACCGGTTCGGCGCTGCGCGAGGCCGAGAGCGTAATCGAAGAGG
CGGAGCGGACCAAGCTGAGCGAACGGGACAGCCTGCTCGTTCTCGATCTGCTCGAAAATCCCCCTCCGGCGAATGCAAAA
TTGCGCGCTGCCATCGCCGCGATGCCCAAGCTCGCATGA

Structures

Toxin

• AlphaFold DB: A0A126RRI7