Detailed information of TA system TA045067

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 718414..718978
• Replicon: chromosome
• Accession: NZ_CP005083
• Organism: Sphingobium sp. TKS

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A126RI07
• Locus tag: K426_RS03725
• Protein ID: WP_066553922.1
• Coordinates: 718658..718978 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K426_RS03720
• Protein ID: WP_066561340.1
• Coordinates: 718414..718674 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K426_RS03710	714158..715351	-	1194	WP_066553916.1	hypothetical protein	-
K426_RS03715	715578..718331	+	2754	WP_066553919.1	class I SAM-dependent DNA methyltransferase	-
K426_RS03720	718414..718674	+	261	WP_066561340.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K426_RS03725	718658..718978	+	321	WP_066553922.1	type II toxin-antitoxin system YafQ family toxin	Toxin
K426_RS03730	718975..721041	+	2067	WP_066553927.1	DEAD/DEAH box helicase	-
K426_RS03735	721034..722230	+	1197	WP_066553930.1	GIY-YIG nuclease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	560094..729888	169794

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (12-105)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11907.55 Da
• Isoelectric Point: 8.0737

>T45067 WP_066553922.1 NZ_CP005083:718658-718978 [Sphingobium sp. TKS]
MAKPSKRAVTPRAAEYAKAFHKDWERLSRSGRFDMAQLKEAMLLLIANDAPLGPEWRDHALKGDWQGSRECHIGGDFLLI
YDVDDAAGKSGTIYFVRAGTHSELFK

Nucleotide

• Length: 321 bp

>T45067 NZ_CP005083:718658-718978 [Sphingobium sp. TKS]
ATGGCAAAGCCCAGTAAGCGCGCCGTCACGCCGCGCGCGGCCGAGTACGCCAAGGCCTTTCACAAGGATTGGGAACGCCT
GTCGCGCTCCGGACGGTTTGACATGGCCCAGCTCAAGGAAGCGATGCTCCTGCTGATCGCCAATGACGCGCCGCTCGGCC
CAGAGTGGCGCGATCATGCGCTGAAAGGCGATTGGCAGGGGAGCCGGGAATGCCACATCGGCGGCGATTTCCTGCTGATC
TATGACGTTGACGACGCTGCGGGGAAAAGTGGGACCATCTACTTCGTCCGTGCGGGCACCCACAGTGAGCTGTTCAAATG
A

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9490.95 Da
• Isoelectric Point: 6.4673

>AT45067 WP_066561340.1 NZ_CP005083:718414-718674 [Sphingobium sp. TKS]
MLHVRLDNELKARATEALAAMGLTASDAVRLLFHRIAVDQAFPLELKVPNAETRAALEEVAQMKADRRVRFANADEMFAA
LDGKAQ

Nucleotide

• Length: 261 bp

>AT45067 NZ_CP005083:718414-718674 [Sphingobium sp. TKS]
ATGCTCCATGTCCGCTTGGACAACGAATTGAAGGCGAGAGCCACCGAGGCGCTGGCGGCGATGGGGCTGACGGCTTCCGA
TGCCGTGCGCCTGCTGTTCCACCGCATCGCGGTCGATCAGGCGTTCCCGCTGGAACTGAAGGTGCCCAACGCCGAAACCC
GCGCCGCGCTGGAAGAGGTGGCACAGATGAAGGCAGATCGGCGCGTCCGCTTTGCCAATGCTGATGAGATGTTCGCGGCG
CTCGATGGCAAAGCCCAGTAA

Structures

Toxin

• AlphaFold DB: A0A126RI07