Detailed information of TA system TA045046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 41534..42354
• Replicon: chromosome
• Accession: NZ_CP004887
• Organism: Klebsiella michiganensis HKOPL1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: J415_RS00225
• Protein ID: WP_001054379.1
• Coordinates: 41534..41791 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: J415_RS00230
• Protein ID: WP_038422882.1
• Coordinates: 41803..42354 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J415_RS27560	37797..38375	+	579	WP_071889542.1	inovirus-type Gp2 protein	-
J415_RS27565	38483..38692	+	210	WP_075038942.1	AlpA family phage regulatory protein	-
J415_RS00205	38660..39187	-	528	WP_051597147.1	hypothetical protein	-
J415_RS00210	39325..39750	-	426	Protein_40	DUF1062 domain-containing protein	-
J415_RS00215	40182..40574	+	393	WP_000493336.1	VOC family protein	-
J415_RS00220	40859..41194	+	336	WP_038422881.1	GNAT family N-acetyltransferase	-
J415_RS00225	41534..41791	+	258	WP_001054379.1	YjhX family toxin	Toxin
J415_RS00230	41803..42354	+	552	WP_038422882.1	N-acetyltransferase	Antitoxin
J415_RS00235	42406..43152	+	747	WP_038422884.1	class I SAM-dependent methyltransferase	-
J415_RS00240	43279..43530	+	252	WP_004110826.1	hypothetical protein	-
J415_RS00245	43578..43970	+	393	WP_000493325.1	VOC family protein	-
J415_RS00250	44448..45047	+	600	WP_038423372.1	DUF1819 family protein	-
J415_RS00255	45044..45658	+	615	WP_077254712.1	DUF1788 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T45046 WP_001054379.1 NZ_CP004887:41534-41791 [Klebsiella michiganensis HKOPL1]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T45046 NZ_CP004887:41534-41791 [Klebsiella michiganensis HKOPL1]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGTTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20448.53 Da
• Isoelectric Point: 6.5656

>AT45046 WP_038422882.1 NZ_CP004887:41803-42354 [Klebsiella michiganensis HKOPL1]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLKLMGCQMVFVLGHTTYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMNLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT45046 NZ_CP004887:41803-42354 [Klebsiella michiganensis HKOPL1]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTGGCCC
GGCATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAAGTTGATGGGCTGCCAGATGGTTTTTGTTCTCGGCCACACCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGAACCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030