Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 131564..132594 | Replicon | plasmid pP73B |
| Accession | NZ_CP004395 | ||
| Organism | Celeribacter indicus strain P73 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | P73_RS23440 | Protein ID | WP_007803220.1 |
| Coordinates | 131564..132133 (-) | Length | 190 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | V9WPQ5 |
| Locus tag | P73_RS23445 | Protein ID | WP_007803221.1 |
| Coordinates | 132130..132594 (-) | Length | 155 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P73_RS23415 | 127138..127650 | - | 513 | Protein_133 | IS110 family transposase | - |
| P73_RS23420 | 127722..128513 | - | 792 | WP_007803213.1 | TniQ family protein | - |
| P73_RS23425 | 128510..129388 | - | 879 | WP_007803215.1 | TniB family NTP-binding protein | - |
| P73_RS23430 | 129479..130411 | - | 933 | WP_007803217.1 | IS5-like element ISRhba5 family transposase | - |
| P73_RS23435 | 130663..131505 | + | 843 | WP_007803218.1 | hypothetical protein | - |
| P73_RS23440 | 131564..132133 | - | 570 | WP_007803220.1 | PIN domain-containing protein | Toxin |
| P73_RS23445 | 132130..132594 | - | 465 | WP_007803221.1 | excisionase family DNA-binding protein | Antitoxin |
| P73_RS23450 | 132744..133811 | - | 1068 | WP_007803223.1 | hypothetical protein | - |
| P73_RS23455 | 134038..134922 | + | 885 | WP_043872288.1 | recombinase family protein | - |
| P73_RS23460 | 135001..135396 | - | 396 | WP_043872289.1 | PIN domain-containing protein | - |
| P73_RS25325 | 135386..135613 | - | 228 | WP_009503866.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..135821 | 135821 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 190 a.a. Molecular weight: 21163.39 Da Isoelectric Point: 5.2804
>T45042 WP_007803220.1 NZ_CP004395:c132133-131564 [Celeribacter indicus]
MSQYTVLFDANVLYPAPMRDALMQLAVTDLFKAKWTADIHREWIDALLRNEPHRERAALERTRDLMDRATRDCLVTGYEA
LVPALTLPDPDDRHVLAAAIVGRCDAIVTQNLKDFPPAALAPFGIETQHPDDFFRNQLSLAPGLVCSALRKVRARLKNPL
KSVDEYLAILTQQGLVATVADLEQFADLL
MSQYTVLFDANVLYPAPMRDALMQLAVTDLFKAKWTADIHREWIDALLRNEPHRERAALERTRDLMDRATRDCLVTGYEA
LVPALTLPDPDDRHVLAAAIVGRCDAIVTQNLKDFPPAALAPFGIETQHPDDFFRNQLSLAPGLVCSALRKVRARLKNPL
KSVDEYLAILTQQGLVATVADLEQFADLL
Download Length: 570 bp
>T45042 NZ_CP004395:c132133-131564 [Celeribacter indicus]
ATGAGCCAGTACACGGTCCTGTTCGATGCGAACGTCCTTTATCCCGCGCCGATGCGCGATGCACTGATGCAGTTGGCGGT
CACAGACCTTTTCAAGGCCAAGTGGACGGCCGATATCCATCGGGAGTGGATTGATGCGCTTCTGCGCAATGAACCTCATC
GGGAGCGCGCCGCGCTGGAACGAACTCGCGACTTGATGGACAGGGCCACACGCGACTGTCTGGTCACCGGCTACGAGGCA
TTGGTGCCGGCCCTAACACTGCCGGACCCTGACGATCGGCACGTTCTGGCGGCGGCAATCGTTGGGCGCTGTGACGCGAT
CGTCACGCAGAACCTGAAGGACTTCCCACCAGCGGCACTTGCGCCCTTTGGCATCGAGACCCAACACCCTGACGACTTTT
TCCGGAACCAACTGTCTCTCGCGCCCGGTCTGGTCTGTTCCGCGCTGCGGAAAGTTCGCGCGCGCCTCAAGAATCCGCTC
AAAAGCGTCGACGAGTATCTCGCGATCCTGACACAGCAGGGGTTGGTCGCCACGGTTGCCGACCTGGAGCAATTCGCCGA
CCTGCTTTGA
ATGAGCCAGTACACGGTCCTGTTCGATGCGAACGTCCTTTATCCCGCGCCGATGCGCGATGCACTGATGCAGTTGGCGGT
CACAGACCTTTTCAAGGCCAAGTGGACGGCCGATATCCATCGGGAGTGGATTGATGCGCTTCTGCGCAATGAACCTCATC
GGGAGCGCGCCGCGCTGGAACGAACTCGCGACTTGATGGACAGGGCCACACGCGACTGTCTGGTCACCGGCTACGAGGCA
TTGGTGCCGGCCCTAACACTGCCGGACCCTGACGATCGGCACGTTCTGGCGGCGGCAATCGTTGGGCGCTGTGACGCGAT
CGTCACGCAGAACCTGAAGGACTTCCCACCAGCGGCACTTGCGCCCTTTGGCATCGAGACCCAACACCCTGACGACTTTT
TCCGGAACCAACTGTCTCTCGCGCCCGGTCTGGTCTGTTCCGCGCTGCGGAAAGTTCGCGCGCGCCTCAAGAATCCGCTC
AAAAGCGTCGACGAGTATCTCGCGATCCTGACACAGCAGGGGTTGGTCGCCACGGTTGCCGACCTGGAGCAATTCGCCGA
CCTGCTTTGA
Antitoxin
Download Length: 155 a.a. Molecular weight: 16891.48 Da Isoelectric Point: 6.4929
>AT45042 WP_007803221.1 NZ_CP004395:c132594-132130 [Celeribacter indicus]
MNMLAHRHLPPTPQDAAIARVSGQALSRFAQARAPLKLRVTDSEQMEPIELPAGAVSLLMEILEAMAAGRGVTIIPENAE
LSTVQAAEVLNVSRPFLIKLLEDGAIPHRKVGKHRRVRMEDVMSYKAAIDTEREAALDQLAADAQEQDMGYRSK
MNMLAHRHLPPTPQDAAIARVSGQALSRFAQARAPLKLRVTDSEQMEPIELPAGAVSLLMEILEAMAAGRGVTIIPENAE
LSTVQAAEVLNVSRPFLIKLLEDGAIPHRKVGKHRRVRMEDVMSYKAAIDTEREAALDQLAADAQEQDMGYRSK
Download Length: 465 bp
>AT45042 NZ_CP004395:c132594-132130 [Celeribacter indicus]
ATGAACATGCTGGCACACCGACATCTTCCGCCCACGCCGCAGGACGCAGCGATTGCGCGCGTCTCTGGCCAGGCATTGTC
ACGCTTCGCCCAGGCGCGCGCGCCGTTGAAACTTCGTGTGACGGACTCCGAGCAGATGGAGCCGATCGAGCTTCCTGCGG
GCGCCGTATCGCTGCTCATGGAGATCCTCGAGGCGATGGCAGCGGGGCGGGGGGTCACCATCATCCCCGAGAACGCCGAA
CTCTCGACCGTACAGGCCGCTGAGGTTCTGAACGTCTCGCGTCCGTTCCTGATCAAGCTGCTCGAGGATGGTGCCATACC
GCATCGGAAGGTCGGCAAGCATCGCCGCGTCCGCATGGAAGACGTGATGTCCTACAAGGCCGCGATCGATACCGAGCGTG
AAGCTGCGCTCGATCAACTGGCCGCCGACGCTCAAGAGCAGGACATGGGCTACCGCTCGAAATGA
ATGAACATGCTGGCACACCGACATCTTCCGCCCACGCCGCAGGACGCAGCGATTGCGCGCGTCTCTGGCCAGGCATTGTC
ACGCTTCGCCCAGGCGCGCGCGCCGTTGAAACTTCGTGTGACGGACTCCGAGCAGATGGAGCCGATCGAGCTTCCTGCGG
GCGCCGTATCGCTGCTCATGGAGATCCTCGAGGCGATGGCAGCGGGGCGGGGGGTCACCATCATCCCCGAGAACGCCGAA
CTCTCGACCGTACAGGCCGCTGAGGTTCTGAACGTCTCGCGTCCGTTCCTGATCAAGCTGCTCGAGGATGGTGCCATACC
GCATCGGAAGGTCGGCAAGCATCGCCGCGTCCGCATGGAAGACGTGATGTCCTACAAGGCCGCGATCGATACCGAGCGTG
AAGCTGCGCTCGATCAACTGGCCGCCGACGCTCAAGAGCAGGACATGGGCTACCGCTCGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|