Detailed information of TA system TA045041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3452656..3453294
• Replicon: chromosome
• Accession: NZ_CP004393
• Organism: Celeribacter indicus strain P73

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0B5E401
• Locus tag: P73_RS25145
• Protein ID: WP_074743072.1
• Coordinates: 3452656..3452841 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: P73_RS17050
• Protein ID: WP_043870497.1
• Coordinates: 3452896..3453294 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P73_RS17030	3449286..3450503	+	1218	WP_043871881.1	multidrug effflux MFS transporter	-
P73_RS17035	3450590..3451987	+	1398	WP_043870496.1	helix-turn-helix transcriptional regulator	-
P73_RS25145	3452656..3452841	+	186	WP_074743072.1	type II toxin-antitoxin system HicA family toxin	Toxin
P73_RS17050	3452896..3453294	+	399	WP_043870497.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
P73_RS17060	3453564..3454256	-	693	WP_202966912.1	thermonuclease family protein	-
P73_RS17065	3454335..3456017	-	1683	WP_082033379.1	iron ABC transporter permease	-
P73_RS17070	3456208..3457086	+	879	WP_043870498.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6908.05 Da
• Isoelectric Point: 11.3704

>T45041 WP_074743072.1 NZ_CP004393:3452656-3452841 [Celeribacter indicus]
METDSREIIKRLLSEGFEKVSQKGSHVKLRKGTRTVIVPHPKRDLPRGTARQIAKAAGWIE

Nucleotide

• Length: 186 bp

>T45041 NZ_CP004393:3452656-3452841 [Celeribacter indicus]
ATGGAAACGGACAGCCGAGAGATCATCAAGCGGCTTCTTTCCGAAGGTTTCGAAAAGGTCTCACAGAAGGGGTCACATGT
GAAACTGAGGAAGGGCACCCGGACAGTGATCGTTCCACACCCCAAGCGGGATTTGCCGAGAGGCACGGCCCGCCAAATCG
CAAAGGCTGCGGGCTGGATCGAATGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14523.39 Da
• Isoelectric Point: 4.1197

>AT45041 WP_043870497.1 NZ_CP004393:3452896-3453294 [Celeribacter indicus]
MYYWAIVHHDEGSAYGVTFPDLDGCFAASDDQEKVMPAAIEALDLYFEDMAEIPGAMSLDAVRETYREDLLEGAYLIQVP
LIPRTTKSVRVNLSFDQGLLSAIDSAADRVGLNRSAFLAMAAKEKIRDTEAA

Nucleotide

• Length: 399 bp

>AT45041 NZ_CP004393:3452896-3453294 [Celeribacter indicus]
ATGTACTACTGGGCGATTGTCCATCACGACGAAGGAAGCGCATACGGCGTGACCTTCCCGGATCTGGACGGGTGCTTTGC
CGCCTCTGACGATCAGGAAAAAGTCATGCCGGCAGCAATCGAAGCTCTCGATCTGTATTTCGAGGATATGGCGGAAATTC
CCGGCGCAATGTCTCTGGATGCAGTTCGGGAGACATACAGGGAAGATCTCTTGGAAGGGGCCTATCTCATCCAGGTCCCG
CTGATCCCGCGCACAACGAAATCCGTGCGCGTGAATCTCAGCTTTGATCAGGGGCTCCTGTCAGCCATCGACAGCGCCGC
AGATCGTGTCGGATTAAACCGCTCTGCCTTCCTCGCGATGGCGGCAAAGGAAAAGATCCGAGACACCGAAGCTGCATGA

Structures

Toxin

• AlphaFold DB: A0A0B5E401