Detailed information of TA system TA045040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2276019..2276878
• Replicon: chromosome
• Accession: NZ_CP004393
• Organism: Celeribacter indicus strain P73

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: P73_RS11435
• Protein ID: WP_043869650.1
• Coordinates: 2276019..2276549 (-)
• Length: 177 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A0B5DU44
• Locus tag: P73_RS11440
• Protein ID: WP_043869651.1
• Coordinates: 2276537..2276878 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P73_RS25630	2271278..2271706	-	429	WP_139267242.1	hypothetical protein	-
P73_RS11420	2272098..2274200	+	2103	WP_043869647.1	ParB/RepB/Spo0J family partition protein	-
P73_RS11425	2274383..2274799	+	417	WP_043869648.1	hypothetical protein	-
P73_RS11430	2275042..2276001	-	960	WP_074743507.1	hypothetical protein	-
P73_RS11435	2276019..2276549	-	531	WP_043869650.1	GNAT family N-acetyltransferase	Toxin
P73_RS11440	2276537..2276878	-	342	WP_043869651.1	DUF1778 domain-containing protein	Antitoxin
P73_RS11445	2277660..2277977	+	318	WP_043869652.1	DUF736 domain-containing protein	-
P73_RS11450	2278379..2279575	+	1197	WP_043869653.1	hypothetical protein	-
P73_RS11455	2279889..2280104	+	216	WP_043869654.1	hypothetical protein	-
P73_RS11460	2280031..2280669	+	639	WP_082033209.1	DUF2285 domain-containing protein	-
P73_RS11465	2280705..2280992	-	288	WP_043869656.1	DUF2285 domain-containing protein	-
P73_RS11470	2281462..2281734	+	273	WP_043869366.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (51-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (24-112)

Sequences

Toxin

Protein

• Length: 177 a.a.
• Molecular weight: 18952.51 Da
• Isoelectric Point: 5.0072

>T45040 WP_043869650.1 NZ_CP004393:c2276549-2276019 [Celeribacter indicus]
MAEIDDTPDHPELPLSAPVPLTAEHDLSAFDCGEPALNDWLRHRALKNESRFSRTYVVCAGNQVVGYFCISAGSVERGAA
PGKVRRNAPDQIPVSIIGRLAVDLDHAGKGLGADLLADALHRIALASQSIGIGAVMVQAKDEAAKHFYLRCAEFVEYPED
SRTLFLPIETVVAAFS

Nucleotide

• Length: 531 bp

>T45040 NZ_CP004393:c2276549-2276019 [Celeribacter indicus]
ATGGCAGAAATAGACGACACGCCCGACCATCCCGAATTGCCACTGTCTGCTCCTGTTCCTCTGACGGCAGAGCATGATCT
TTCGGCATTCGACTGCGGTGAGCCTGCATTGAACGACTGGCTGCGCCACCGGGCCTTGAAGAACGAAAGCCGGTTCTCGC
GCACCTATGTCGTGTGTGCGGGCAATCAGGTCGTCGGTTATTTTTGCATTTCGGCCGGGTCGGTCGAGCGTGGTGCAGCG
CCCGGCAAGGTGCGGCGCAACGCGCCCGACCAGATTCCGGTCTCGATCATCGGCCGGCTGGCCGTTGACCTCGACCACGC
AGGAAAGGGCCTCGGTGCGGATCTTTTGGCGGACGCGCTGCACCGGATCGCTCTGGCTTCGCAAAGCATCGGCATCGGAG
CTGTGATGGTCCAGGCGAAGGATGAGGCGGCCAAACACTTCTATCTGCGCTGTGCCGAGTTCGTCGAATACCCCGAAGAC
AGCCGGACGCTGTTCCTGCCTATCGAAACCGTGGTCGCGGCGTTTAGCTAG

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12395.21 Da
• Isoelectric Point: 10.7841

>AT45040 WP_043869651.1 NZ_CP004393:c2276878-2276537 [Celeribacter indicus]
MTKARIAPSESARSATTAVAVRASTADTKGSINLRIETGTRQLIDDAAAVLGKTRTEFMVESARRQAVDVLLDQRLFTLD
PERYDAFMQALDNPPAPGPKLKALLRRTPAWQK

Nucleotide

• Length: 342 bp

>AT45040 NZ_CP004393:c2276878-2276537 [Celeribacter indicus]
ATGACCAAAGCTCGTATCGCCCCTTCGGAATCTGCCCGTTCTGCGACCACCGCCGTTGCAGTTCGTGCCTCTACGGCTGA
CACCAAGGGCAGCATCAATCTGCGGATCGAGACTGGCACGCGCCAGCTCATCGACGATGCGGCGGCGGTGCTCGGCAAGA
CGCGCACCGAGTTCATGGTGGAAAGCGCCCGGCGGCAAGCGGTCGATGTGCTGCTCGACCAGCGCTTGTTCACGCTCGAC
CCCGAGCGCTACGACGCCTTCATGCAAGCGCTCGACAATCCGCCCGCACCGGGGCCGAAGCTCAAAGCCCTGCTGCGCCG
GACCCCGGCATGGCAGAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A0B5DU44