Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1864527..1865200 Replicon chromosome
Accession NZ_CP004393
Organism Celeribacter indicus strain P73

Toxin (Protein)


Gene name vapC Uniprot ID A0A0B5E0H7
Locus tag P73_RS09430 Protein ID WP_043869371.1
Coordinates 1864527..1864949 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0B5E1Z8
Locus tag P73_RS09435 Protein ID WP_043869372.1
Coordinates 1864946..1865200 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P73_RS09410 1860748..1861389 - 642 WP_082033164.1 DUF2285 domain-containing protein -
P73_RS09415 1861316..1861531 - 216 WP_043869368.1 hypothetical protein -
P73_RS09420 1861845..1863041 - 1197 WP_043869369.1 hypothetical protein -
P73_RS09425 1863441..1863761 - 321 WP_043869370.1 DUF736 domain-containing protein -
P73_RS09430 1864527..1864949 - 423 WP_043869371.1 type II toxin-antitoxin system VapC family toxin Toxin
P73_RS09435 1864946..1865200 - 255 WP_043869372.1 plasmid stabilization protein Antitoxin
P73_RS09440 1865278..1865694 - 417 WP_043869373.1 hypothetical protein -
P73_RS09445 1865944..1867956 - 2013 WP_202966944.1 ParB/RepB/Spo0J family partition protein -
P73_RS24890 1868448..1868756 + 309 WP_082033165.1 XRE family transcriptional regulator -
P73_RS09450 1868776..1870185 + 1410 WP_043869374.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1762423..2069539 307116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14904.01 Da        Isoelectric Point: 4.6780

>T45039 WP_043869371.1 NZ_CP004393:c1864949-1864527 [Celeribacter indicus]
MIVLDTNVVSEAMKPEPDPAVRDWLDEQAAETLYISSVTVAELLFGIGALPNGRRKQKLAATLDGLLPLFEGRILAFDTD
AARHYADLAVAARKAGKGFPTPDGYIAAIATAHGFTIATRDASAFDAAGIPVIDPWMAQH

Download         Length: 423 bp

>T45039 NZ_CP004393:c1864949-1864527 [Celeribacter indicus]
ATGATCGTTCTGGATACGAATGTCGTCTCCGAGGCGATGAAGCCGGAACCGGACCCCGCCGTGCGCGACTGGCTGGACGA
GCAGGCTGCCGAAACCCTTTACATCTCCAGCGTCACCGTCGCGGAACTCCTGTTCGGCATCGGCGCGCTGCCGAATGGAC
GGCGCAAGCAGAAGCTCGCTGCCACGCTCGACGGGCTGCTGCCCCTGTTCGAGGGCAGAATCCTCGCCTTCGATACCGAC
GCCGCCCGCCACTATGCCGACCTTGCCGTTGCGGCCCGCAAGGCGGGCAAGGGCTTTCCCACGCCGGACGGCTATATCGC
CGCCATCGCAACCGCCCACGGTTTCACGATTGCGACCCGTGATGCCAGCGCCTTCGACGCGGCAGGCATTCCGGTCATCG
ACCCTTGGATGGCACAGCACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9240.47 Da        Isoelectric Point: 8.9520

>AT45039 WP_043869372.1 NZ_CP004393:c1865200-1864946 [Celeribacter indicus]
MPAVTIRNLSDETHRALKLRAAHHGRSTEAEMRDILESAVRPAERLRLGSALSALSRKAGLTNADFEALEQARDKTPATP
MSFE

Download         Length: 255 bp

>AT45039 NZ_CP004393:c1865200-1864946 [Celeribacter indicus]
ATGCCCGCCGTCACCATTCGCAACCTCTCCGACGAGACCCATCGCGCCCTCAAGTTGCGCGCGGCCCATCACGGCCGCAG
CACCGAGGCCGAAATGCGCGACATTCTGGAATCGGCGGTGCGTCCCGCCGAGCGCCTGCGCCTCGGCTCCGCCCTGTCGG
CGTTGAGCCGCAAGGCCGGGCTGACCAATGCCGATTTTGAGGCGTTGGAACAGGCCCGCGACAAGACGCCCGCCACGCCG
ATGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5E0H7

Antitoxin

Source ID Structure
AlphaFold DB A0A0B5E1Z8

References