45033

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 3040333..3040892 Replicon chromosome
Accession NZ_CP004387
Organism Alcanivorax pacificus W11-5

Toxin (Protein)


Gene name parE Uniprot ID A0A0B4XS50
Locus tag S7S_RS13435 Protein ID WP_008734250.1
Coordinates 3040333..3040626 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID A0A0B4XRL6
Locus tag S7S_RS13440 Protein ID WP_008734248.1
Coordinates 3040614..3040892 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S7S_RS13400 3035384..3036190 + 807 WP_008734260.1 SDR family NAD(P)-dependent oxidoreductase -
S7S_RS13405 3036219..3037115 + 897 WP_008734259.1 DMT family transporter -
S7S_RS13410 3037145..3037495 + 351 WP_008734257.1 non-heme iron oxygenase ferredoxin subunit -
S7S_RS13415 3037498..3038511 + 1014 WP_008734254.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
S7S_RS13420 3038527..3039117 + 591 WP_008734253.1 CoA pyrophosphatase -
S7S_RS13425 3039181..3039939 + 759 WP_008734251.1 IclR family transcriptional regulator -
S7S_RS13435 3040333..3040626 - 294 WP_008734250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
S7S_RS13440 3040614..3040892 - 279 WP_008734248.1 CopG family ribbon-helix-helix protein Antitoxin
S7S_RS13445 3041318..3041725 + 408 WP_008734246.1 hypothetical protein -
S7S_RS13450 3041871..3042245 + 375 WP_008734245.1 hypothetical protein -
S7S_RS13455 3042276..3042611 - 336 WP_035203502.1 DUF1820 family protein -
S7S_RS13460 3043062..3044279 + 1218 WP_008734243.1 cytochrome c oxidase subunit II -
S7S_RS13465 3044295..3045881 + 1587 WP_008734242.1 cytochrome c oxidase subunit I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11059.68 Da        Isoelectric Point: 7.2027

>T45033 WP_008734250.1 NZ_CP004387:c3040626-3040333 [Alcanivorax pacificus W11-5]
MPQVIFAPAALRDLQRLRDFLRPKNADAARRAGEAIRQGVQVLSAHPRMGLLVEDLPEQYREWLIDFGDSGYVARYRIDD
DAVIILAVRHQKEVGFS

Download         Length: 294 bp

>T45033 NZ_CP004387:c3040626-3040333 [Alcanivorax pacificus W11-5]
ATGCCACAAGTGATTTTTGCCCCGGCCGCGCTCCGGGATTTGCAGCGGCTGCGTGATTTCTTGCGCCCCAAGAACGCCGA
CGCTGCCCGCCGGGCCGGTGAAGCGATCCGGCAGGGGGTGCAAGTATTGAGCGCGCACCCGCGAATGGGGCTGCTGGTGG
AAGACCTCCCGGAACAATACCGGGAGTGGCTCATCGACTTTGGCGATAGTGGCTACGTTGCCCGATACCGCATTGACGAC
GATGCGGTGATCATTCTTGCTGTGCGGCACCAGAAGGAAGTGGGCTTCTCATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10788.07 Da        Isoelectric Point: 6.0921

>AT45033 WP_008734248.1 NZ_CP004387:c3040892-3040614 [Alcanivorax pacificus W11-5]
MASATSIKLDDELKGRVQHLAESRRRTSHWIMREAIRQYVEREEKREALNRDTIKAWEEFQATGLHATADEVDKWLESWG
TENELPAPVCHK

Download         Length: 279 bp

>AT45033 NZ_CP004387:c3040892-3040614 [Alcanivorax pacificus W11-5]
ATGGCATCCGCGACCTCGATCAAGCTCGATGACGAACTCAAAGGCCGTGTGCAGCACCTCGCTGAATCCCGGCGCCGCAC
GTCGCACTGGATCATGCGGGAGGCTATCAGGCAGTACGTTGAACGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGA
TCAAGGCGTGGGAGGAATTTCAGGCCACCGGGCTGCACGCCACGGCAGACGAAGTCGATAAATGGCTGGAGAGTTGGGGA
ACTGAAAACGAGTTGCCCGCGCCCGTATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B4XS50

Antitoxin

Source ID Structure
AlphaFold DB A0A0B4XRL6

References