Detailed information of TA system TA045032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2909831..2910387
• Replicon: chromosome
• Accession: NZ_CP004387
• Organism: Alcanivorax pacificus W11-5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: S7S_RS12870
• Protein ID: WP_035206065.1
• Coordinates: 2909831..2910193 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: S7S_RS12875
• Protein ID: WP_008740330.1
• Coordinates: 2910196..2910387 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S7S_RS12850	2904845..2905054	+	210	WP_008740323.1	hypothetical protein	-
S7S_RS12855	2905229..2905825	+	597	WP_008740324.1	tRNA (pseudouridine(54)-N(1))-methyltransferase TrmY	-
S7S_RS19340	2905900..2906073	-	174	WP_082027721.1	integrase core domain-containing protein	-
S7S_RS12860	2906272..2906601	-	330	WP_008740327.1	helix-turn-helix domain-containing protein	-
S7S_RS19685	2907385..2907918	-	534	WP_144401665.1	hypothetical protein	-
S7S_RS19345	2909430..2909585	+	156	WP_082027722.1	transposase	-
S7S_RS12870	2909831..2910193	-	363	WP_035206065.1	type II toxin-antitoxin system VapC family toxin	Toxin
S7S_RS12875	2910196..2910387	-	192	WP_008740330.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
S7S_RS12880	2910906..2911370	-	465	WP_008740331.1	type II toxin-antitoxin system YhaV family toxin	-
S7S_RS12885	2911370..2911687	-	318	WP_008740333.1	type II toxin-antitoxin system PrlF family antitoxin	-
S7S_RS18910	2911730..2912377	-	648	WP_082027803.1	hypothetical protein	-
S7S_RS12895	2913531..2914244	+	714	WP_008740336.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
S7S_RS12900	2914292..2915020	+	729	WP_008740337.1	DsbC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2890656..2919214	28558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13533.62 Da
• Isoelectric Point: 7.1155

>T45032 WP_035206065.1 NZ_CP004387:c2910193-2909831 [Alcanivorax pacificus W11-5]
VILADTSIWIDHLRSGNEHLAVLLDRAEVCMHPFIRGELACGNLQQRTTILALMRNLSSARVATDDEVLYMIEHHALMGQ
GLGYIDMHLLAAVRLSDGVRLWTRDRRLNAAAQRLGYGYH

Nucleotide

• Length: 363 bp

>T45032 NZ_CP004387:c2910193-2909831 [Alcanivorax pacificus W11-5]
GTGATCCTCGCGGACACATCAATATGGATTGATCATTTGCGCTCCGGCAACGAGCACCTTGCTGTCTTGCTGGATAGAGC
AGAGGTATGCATGCACCCGTTCATACGCGGGGAGCTGGCGTGTGGAAACCTGCAACAACGCACGACAATTCTGGCGTTGA
TGAGGAACTTGTCGTCTGCTCGTGTGGCTACAGACGATGAGGTGCTTTATATGATCGAACACCACGCCTTGATGGGGCAG
GGGCTAGGATACATAGACATGCATTTGCTGGCGGCAGTGAGGCTGTCCGATGGCGTTCGGCTTTGGACGCGTGACAGGCG
TTTAAATGCTGCGGCGCAGCGGCTTGGCTATGGATATCATTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 6959.88 Da
• Isoelectric Point: 5.0506

>AT45032 WP_008740330.1 NZ_CP004387:c2910387-2910196 [Alcanivorax pacificus W11-5]
MRTTMNIDDELLAEAQRVTGVSERAALVREGLAALIQRESARRLAKLGGTEPQLDDVPRNRAE

Nucleotide

• Length: 192 bp

>AT45032 NZ_CP004387:c2910387-2910196 [Alcanivorax pacificus W11-5]
ATGCGCACCACAATGAATATTGACGACGAGTTACTGGCCGAAGCCCAGCGGGTTACGGGAGTTTCCGAGCGAGCCGCACT
GGTTCGTGAGGGGTTGGCTGCATTGATCCAGAGAGAAAGCGCCCGCCGACTGGCAAAGTTGGGAGGCACTGAGCCTCAGT
TGGATGACGTTCCCCGCAATAGGGCAGAGTAA