Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2852158..2853638 Replicon chromosome
Accession NZ_CP004387
Organism Alcanivorax pacificus W11-5

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A0B4XR67
Locus tag S7S_RS12635 Protein ID WP_008738731.1
Coordinates 2852158..2853417 (-) Length 420 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A0B4XKY4
Locus tag S7S_RS12640 Protein ID WP_008738730.1
Coordinates 2853414..2853638 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S7S_RS12625 2848754..2850904 + 2151 WP_008738734.1 fatty acid oxidation complex subunit alpha FadB -
S7S_RS12630 2850928..2852103 + 1176 WP_008738732.1 acetyl-CoA C-acyltransferase FadA -
S7S_RS12635 2852158..2853417 - 1260 WP_008738731.1 type II toxin-antitoxin system HipA family toxin Toxin
S7S_RS12640 2853414..2853638 - 225 WP_008738730.1 helix-turn-helix domain-containing protein Antitoxin
S7S_RS19670 2853642..2853884 - 243 WP_144401660.1 hypothetical protein -
S7S_RS12645 2853924..2856770 - 2847 WP_008738729.1 hypothetical protein -
S7S_RS12650 2856864..2857415 - 552 WP_008738726.1 outer membrane beta-barrel protein -
S7S_RS12655 2857739..2857918 - 180 WP_035205388.1 hypothetical protein -
S7S_RS19875 2857915..2858064 - 150 WP_169745570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 420 a.a.        Molecular weight: 45978.75 Da        Isoelectric Point: 6.5851

>T45031 WP_008738731.1 NZ_CP004387:c2853417-2852158 [Alcanivorax pacificus W11-5]
MKLNVTLGDVLCGELSVDQQDRFTFQYLPSYVAHARLALSVSMPLRQEAYPDRVAFPWFENLLPEGLLRHLIADDLGTDV
QNIPGLLARLGGDVAGAVSLSVEGRQADAVSPFHDTPLDERALGRLLEESALHPFLADRAGGPRLSLAGAQQKLPVINDG
QAVRLPLSKPSTHLLKPPSPRFIALPQNEFLCMRAAGLAGLDVAGVALRPYLGSSGEAGVCLQIARYDRRDTGRIHQEDI
CQALSIVSSRKYEQDGGPGMAQLFETVRRHSAMPARDIVELLKRVVFNLLIGNEDAHGKNFSLLYSGKKPRLSPAYDLVS
TSVYAELGRDFAMRIGEATRFEALDEHGFRLFGEQSGTAPARMRTLLLRFLDQAMRAVEQAADEVKPWCEGEAAAMPDNL
LAQCRARCSVLEKLITFLR

Download         Length: 1260 bp

>T45031 NZ_CP004387:c2853417-2852158 [Alcanivorax pacificus W11-5]
ATGAAACTGAACGTGACCCTGGGCGATGTGCTGTGTGGTGAACTGTCTGTCGATCAGCAGGATCGCTTCACTTTTCAGTA
TTTACCTTCCTATGTTGCCCACGCACGGCTTGCGTTGTCGGTCTCCATGCCTTTGCGTCAGGAGGCGTATCCTGACCGTG
TTGCGTTTCCATGGTTTGAGAACCTGCTGCCAGAGGGGCTGCTGCGTCATCTGATCGCGGATGATCTGGGCACCGACGTG
CAGAATATTCCCGGCTTGCTGGCGCGCCTGGGCGGGGATGTGGCGGGGGCGGTGTCGTTGTCCGTCGAGGGGCGGCAGGC
GGACGCGGTGTCGCCGTTTCACGATACACCACTGGATGAGCGGGCGTTGGGGCGGTTGCTGGAAGAATCGGCCTTGCATC
CGTTCCTCGCGGACCGGGCCGGCGGCCCTCGTTTGAGCCTCGCGGGGGCGCAACAGAAGCTGCCGGTGATCAACGATGGG
CAAGCCGTCCGGTTGCCGCTCTCGAAACCCTCCACCCATTTGCTCAAGCCACCGTCGCCACGTTTCATCGCGTTGCCGCA
GAATGAATTCCTGTGCATGCGTGCTGCCGGATTGGCCGGGCTGGATGTCGCGGGTGTGGCCCTCCGGCCTTACCTCGGTT
CCAGCGGGGAGGCCGGGGTATGTTTGCAGATTGCCCGCTATGATCGCCGTGATACGGGACGCATTCATCAGGAAGATATT
TGCCAGGCACTGAGCATCGTGTCCTCACGGAAATACGAGCAGGACGGCGGGCCGGGCATGGCGCAATTGTTTGAAACGGT
GCGCCGTCATTCGGCGATGCCCGCCAGGGACATTGTCGAACTGCTGAAGCGGGTAGTGTTCAACCTGCTGATCGGCAACG
AAGATGCGCATGGCAAGAATTTCTCGCTGCTGTATTCGGGGAAGAAACCGCGGCTGTCGCCCGCCTATGATCTTGTATCG
ACCAGTGTTTATGCTGAACTGGGCCGGGACTTTGCCATGCGCATCGGCGAGGCTACCCGTTTCGAGGCACTTGATGAGCA
CGGCTTCCGGTTATTCGGGGAGCAAAGTGGTACCGCACCGGCGCGCATGCGCACTCTATTGCTGCGTTTCCTTGATCAGG
CGATGCGCGCTGTCGAGCAGGCTGCTGATGAAGTGAAGCCCTGGTGTGAGGGTGAGGCGGCAGCCATGCCCGACAATCTG
CTGGCGCAGTGTCGAGCCCGGTGCAGCGTACTGGAAAAGCTGATCACTTTTTTGCGCTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7819.92 Da        Isoelectric Point: 7.2029

>AT45031 WP_008738730.1 NZ_CP004387:c2853638-2853414 [Alcanivorax pacificus W11-5]
MDSTTLGALVRRVRRRQQLTQQALAAAADVSTRFVHDLEHGKSTAALGLTLRVLAALGIEVQLVAPDGGDDVTP

Download         Length: 225 bp

>AT45031 NZ_CP004387:c2853638-2853414 [Alcanivorax pacificus W11-5]
ATGGACAGTACCACTCTCGGGGCACTCGTGCGTCGGGTCCGCAGGCGGCAGCAGCTGACGCAGCAGGCTTTGGCGGCTGC
GGCAGATGTCAGCACGCGCTTTGTGCATGATCTGGAACATGGAAAATCGACGGCGGCGCTGGGACTGACGTTGCGGGTGT
TGGCTGCTCTGGGTATTGAGGTGCAACTGGTCGCACCCGATGGCGGAGATGACGTAACGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B4XR67

Antitoxin

Source ID Structure
AlphaFold DB A0A0B4XKY4

References