Detailed information of TA system TA045029

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1590468..1590984
• Replicon: chromosome
• Accession: NZ_CP004387
• Organism: Alcanivorax pacificus W11-5

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: S7S_RS07170
• Protein ID: WP_035205662.1
• Coordinates: 1590712..1590984 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0B4XL46
• Locus tag: S7S_RS07165
• Protein ID: WP_008739280.1
• Coordinates: 1590468..1590731 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S7S_RS07140	1586693..1587253	+	561	WP_008739286.1	nitroreductase	-
S7S_RS07145	1587250..1587720	+	471	WP_008739285.1	YiiD C-terminal domain-containing protein	-
S7S_RS07155	1588625..1589446	+	822	WP_008739284.1	hypothetical protein	-
S7S_RS07160	1589461..1590471	+	1011	WP_008739282.1	fatty acid desaturase family protein	-
S7S_RS07165	1590468..1590731	-	264	WP_008739280.1	CopG family transcriptional regulator	Antitoxin
S7S_RS07170	1590712..1590984	-	273	WP_035205662.1	BrnT family toxin	Toxin
S7S_RS07175	1591020..1591271	-	252	WP_008739277.1	hypothetical protein	-
S7S_RS18820	1591598..1592131	-	534	WP_008739275.1	alpha/beta fold hydrolase	-
S7S_RS07185	1592339..1593016	+	678	WP_008739274.1	histidine phosphatase family protein	-
S7S_RS07190	1593028..1594236	+	1209	WP_008739272.1	acyl-CoA dehydrogenase family protein	-
S7S_RS07195	1594262..1595293	+	1032	WP_008739270.1	phosphotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

• CopG antitoxin (5-69)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10728.16 Da
• Isoelectric Point: 8.5680

>T45029 WP_035205662.1 NZ_CP004387:c1590984-1590712 [Alcanivorax pacificus W11-5]
MLRFEYDDTKSRANRLKHGIDFAQARQLWDDPDLLEIPARTLDEPRFLVIGRIGEKHWSAVITYRQHRTRIISVRRARTE
EVALYESEGF

Nucleotide

• Length: 273 bp

>T45029 NZ_CP004387:c1590984-1590712 [Alcanivorax pacificus W11-5]
ATGTTACGGTTCGAATACGACGACACCAAGAGCCGCGCCAACCGGCTCAAGCACGGCATTGATTTTGCCCAGGCCCGACA
ACTCTGGGACGATCCCGACCTGCTTGAAATACCGGCCCGGACCCTGGATGAGCCACGCTTTCTGGTGATCGGTCGTATCG
GGGAGAAACACTGGTCTGCTGTGATTACCTATCGCCAGCATCGCACCCGCATCATTTCCGTCCGCCGCGCACGCACCGAG
GAGGTAGCCCTGTATGAAAGCGAAGGATTTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10146.39 Da
• Isoelectric Point: 6.4705

>AT45029 WP_008739280.1 NZ_CP004387:c1590731-1590468 [Alcanivorax pacificus W11-5]
MKAKDFDRRFDDGEDVSAHLDLRQARRVNTAQKRVNVDFPVWMIEALDREASRLGVTRQSIIKVWLAERLEQASQGTARY
MIHDSDD

Nucleotide

• Length: 264 bp

>AT45029 NZ_CP004387:c1590731-1590468 [Alcanivorax pacificus W11-5]
ATGAAAGCGAAGGATTTTGACCGCCGCTTCGACGACGGCGAGGATGTCAGCGCCCACCTCGACCTCCGTCAGGCACGCCG
CGTCAACACGGCGCAGAAACGGGTCAATGTGGATTTTCCGGTGTGGATGATCGAGGCACTGGACCGCGAAGCCAGCCGTC
TCGGCGTCACCCGGCAATCGATCATCAAGGTGTGGCTGGCCGAACGGCTGGAACAGGCTTCACAGGGCACCGCCCGCTAC
ATGATTCACGACAGCGACGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0B4XL46