Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1328573..1329159 Replicon chromosome
Accession NZ_CP004387
Organism Alcanivorax pacificus W11-5

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B4XM19
Locus tag S7S_RS05905 Protein ID WP_008737935.1
Coordinates 1328905..1329159 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0B4XMP5
Locus tag S7S_RS05900 Protein ID WP_008737933.1
Coordinates 1328573..1328908 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S7S_RS05885 1324294..1325781 + 1488 WP_008737926.1 glycerol kinase GlpK -
S7S_RS05890 1326188..1327333 + 1146 WP_008737928.1 sensor domain-containing diguanylate cyclase -
S7S_RS05895 1327410..1328540 + 1131 WP_008737930.1 GGDEF domain-containing protein -
S7S_RS05900 1328573..1328908 - 336 WP_008737933.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
S7S_RS05905 1328905..1329159 - 255 WP_008737935.1 type II toxin-antitoxin system HicA family toxin Toxin
S7S_RS05910 1329287..1330342 - 1056 WP_008737936.1 ABC transporter ATP-binding protein -
S7S_RS05915 1330398..1331312 - 915 WP_008737939.1 ornithine carbamoyltransferase -
S7S_RS05920 1331309..1332496 - 1188 WP_008737941.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9439.83 Da        Isoelectric Point: 10.1785

>T45028 WP_008737935.1 NZ_CP004387:c1329159-1328905 [Alcanivorax pacificus W11-5]
MKRKHGRTLASLFSRPTPGSVPWKDIEALFQALGAEIEEREGSRVAIFLFGEIRVFHRPHPSPDTDKGAVASIRKWLEDN
GVMP

Download         Length: 255 bp

>T45028 NZ_CP004387:c1329159-1328905 [Alcanivorax pacificus W11-5]
ATGAAACGCAAACACGGCCGGACACTTGCCAGCCTCTTCAGCCGCCCCACGCCCGGCAGCGTGCCGTGGAAAGACATAGA
GGCACTCTTCCAGGCGCTGGGCGCCGAGATTGAGGAGCGTGAAGGGTCTCGTGTCGCCATCTTTCTGTTCGGCGAAATTC
GCGTGTTCCACCGCCCCCATCCTTCGCCGGATACTGACAAGGGCGCAGTGGCCAGCATTCGCAAGTGGCTGGAAGATAAC
GGAGTCATGCCATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.93 Da        Isoelectric Point: 5.1471

>AT45028 WP_008737933.1 NZ_CP004387:c1328908-1328573 [Alcanivorax pacificus W11-5]
MNNIMIINGYRAVIQFDPDIEMFRGEFTGLNGGADFYADSVAALRKEGEISLKVFLDECTKRGVQPNKSYSGKFQVRLPS
ELHEFAADAAQARGQSLNQFVATAIEHELRS

Download         Length: 336 bp

>AT45028 NZ_CP004387:c1328908-1328573 [Alcanivorax pacificus W11-5]
ATGAACAACATCATGATCATCAATGGCTACCGGGCAGTCATTCAATTTGACCCGGACATCGAGATGTTCCGTGGCGAGTT
CACCGGGCTGAACGGCGGGGCTGATTTCTATGCGGACAGCGTTGCTGCCCTGCGCAAAGAAGGTGAAATTTCCCTGAAAG
TCTTTCTTGATGAGTGCACAAAGCGTGGCGTCCAGCCCAACAAATCGTACTCCGGGAAATTCCAGGTCAGGCTGCCTTCC
GAGTTGCATGAATTCGCCGCCGATGCGGCGCAGGCACGGGGTCAAAGCCTGAACCAGTTCGTTGCGACGGCGATTGAACA
CGAGCTCCGCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B4XM19

Antitoxin

Source ID Structure
AlphaFold DB A0A0B4XMP5

References