Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 526638..527151 Replicon chromosome
Accession NZ_CP004387
Organism Alcanivorax pacificus W11-5

Toxin (Protein)


Gene name relB Uniprot ID A0A0B4XKK6
Locus tag S7S_RS02490 Protein ID WP_008739659.1
Coordinates 526885..527151 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B4XIP7
Locus tag S7S_RS02485 Protein ID WP_008739657.1
Coordinates 526638..526892 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S7S_RS02460 522039..522266 - 228 WP_008739647.1 helix-turn-helix transcriptional regulator -
S7S_RS02465 522334..522675 - 342 WP_008739649.1 Rieske (2Fe-2S) protein -
S7S_RS02470 522678..523682 - 1005 WP_008739651.1 adenosine kinase -
S7S_RS02475 523715..526057 + 2343 WP_041025919.1 penicillin-binding protein 1B -
S7S_RS02480 526033..526494 + 462 WP_035205787.1 hypothetical protein -
S7S_RS02485 526638..526892 + 255 WP_008739657.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
S7S_RS02490 526885..527151 + 267 WP_008739659.1 Txe/YoeB family addiction module toxin Toxin
S7S_RS18715 527269..527631 + 363 WP_169745544.1 glutaredoxin family protein -
S7S_RS02500 528083..528574 + 492 WP_008739667.1 DUF4143 domain-containing protein -
S7S_RS02505 529264..529929 + 666 WP_008739668.1 hypothetical protein -
S7S_RS02510 530079..532013 - 1935 WP_008739669.1 PKD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10606.13 Da        Isoelectric Point: 9.7311

>T45026 WP_008739659.1 NZ_CP004387:526885-527151 [Alcanivorax pacificus W11-5]
MIEVLSWTRAAWSDYLYWQTQDKKTLKRINKLVQDAQRSPFEGLGKPEPLKENLTGFWSRRIDDTNRLVYAVDNKQLIII
SCRYHYER

Download         Length: 267 bp

>T45026 NZ_CP004387:526885-527151 [Alcanivorax pacificus W11-5]
ATGATTGAGGTTCTCTCATGGACCCGCGCAGCCTGGTCGGATTATCTGTATTGGCAAACACAAGACAAGAAAACCCTGAA
GCGCATCAATAAGCTTGTTCAGGATGCCCAGCGATCCCCTTTTGAGGGGTTGGGGAAGCCTGAGCCGCTGAAAGAAAATC
TGACGGGGTTTTGGTCCCGGCGTATTGATGATACGAATCGCCTGGTCTATGCCGTTGATAATAAGCAGCTAATAATCATT
TCCTGTCGTTATCACTATGAAAGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9403.59 Da        Isoelectric Point: 5.5721

>AT45026 WP_008739657.1 NZ_CP004387:526638-526892 [Alcanivorax pacificus W11-5]
MRVISFSDARNKLKSVLDQVVGDADYTIITRRDAEDAVVMSLDQFNGLMETVHLLKSPANAAHLSESIRQYRTGKLEQHG
LTDD

Download         Length: 255 bp

>AT45026 NZ_CP004387:526638-526892 [Alcanivorax pacificus W11-5]
ATGCGAGTCATCAGCTTTTCTGATGCCAGAAACAAGCTAAAAAGCGTTCTGGATCAAGTGGTTGGCGATGCTGACTACAC
GATTATCACCCGCAGGGATGCGGAAGACGCGGTGGTGATGTCCCTGGATCAGTTCAATGGTCTTATGGAAACGGTCCATC
TGCTCAAAAGCCCGGCCAATGCGGCGCATCTTTCAGAGTCCATCAGGCAGTACCGGACAGGCAAACTGGAGCAACATGGG
CTGACGGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B4XKK6

Antitoxin

Source ID Structure
AlphaFold DB A0A0B4XIP7

References