Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 156969..158725 Replicon chromosome
Accession NZ_CP004386
Organism Burkholderia thailandensis MSMB59

Toxin (Protein)


Gene name doc Uniprot ID Q2T555
Locus tag BTHA_RS18680 Protein ID WP_009900384.1
Coordinates 156969..157874 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q2T556
Locus tag BTHA_RS18685 Protein ID WP_009897321.1
Coordinates 157871..158725 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHA_RS18650 152364..153452 - 1089 WP_009897338.1 porin -
BTHA_RS18655 153887..154204 + 318 WP_009897336.1 non-heme iron oxygenase ferredoxin subunit -
BTHA_RS18660 154206..154517 + 312 WP_009897334.1 hypothetical protein -
BTHA_RS18665 154552..155619 + 1068 WP_009897333.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BTHA_RS18670 155616..156386 + 771 WP_009897331.1 SDR family oxidoreductase -
BTHA_RS18675 156425..156952 + 528 WP_009897327.1 cupin domain-containing protein -
BTHA_RS18680 156969..157874 + 906 WP_009900384.1 alpha/beta fold hydrolase Toxin
BTHA_RS18685 157871..158725 + 855 WP_009897321.1 IclR family transcriptional regulator Antitoxin
BTHA_RS18690 158722..159519 + 798 WP_009897318.1 SDR family oxidoreductase -
BTHA_RS18695 159512..161185 + 1674 WP_009897317.1 thiamine pyrophosphate-binding protein -
BTHA_RS18700 161178..161993 + 816 WP_009897315.1 aspartate dehydrogenase -
BTHA_RS18705 162015..163505 + 1491 WP_009907742.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-285)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30752.67 Da        Isoelectric Point: 8.4768

>T45024 WP_009900384.1 NZ_CP004386:156969-157874 [Burkholderia thailandensis MSMB59]
MSAISTTTTDASATPFAALLERFAERRAAAGGARTIGYREAGAAYAAHAGRDPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGVSSRVAADSPVASDYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARQAGERLSGLLLISPAGGYGGAPA
DVRAERRDSRLALLASLGPQGLAAERSANMLSAQASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLAHYRGRVAV
AVGADDTITPPAACERIARAAGAGLQVIPRAGHAGYVEAPDAYNALIDAFCRQCDGSRGAA

Download         Length: 906 bp

>T45024 NZ_CP004386:156969-157874 [Burkholderia thailandensis MSMB59]
ATGAGCGCAATCTCCACGACGACTACCGATGCGAGCGCGACGCCGTTCGCCGCGCTGCTCGAACGCTTTGCCGAGCGGCG
CGCGGCCGCAGGCGGCGCGCGTACGATCGGCTATCGCGAAGCGGGCGCAGCGTACGCAGCGCATGCCGGGCGCGATCCCG
TCGTGTTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGTCGCGCG
CTCGCGTGGGACGCGCCGGGCTATGGCGTCTCGTCGCGCGTCGCGGCCGATTCGCCTGTCGCATCCGACTACGCGGCGTC
GCTCGCCGCGTGGCTCGACGCGCTGCGGATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCGTCGCCGGCG
CGTTCGCGCGGCAAGCGGGCGAGCGTCTTTCGGGATTGCTGCTGATTTCTCCGGCGGGCGGCTACGGCGGCGCACCCGCC
GACGTGCGGGCCGAGCGGCGCGACAGCCGCCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGCCGAGCGCAG
CGCAAACATGCTGTCCGCGCAGGCGAGCGACGCCGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCCG
GCTATGCGCAGGCGACGCACCTGCTCGCGAACGCGGACCTCGCGTCCGATCTCGCGCATTATCGCGGCCGCGTCGCGGTC
GCGGTCGGCGCCGACGATACGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCGCGGGCAGCGGGCGCCGGGTTGCAGGT
GATCCCGCGCGCGGGCCATGCCGGCTATGTCGAAGCGCCGGATGCATACAACGCGTTGATCGACGCATTTTGCCGTCAAT
GCGACGGATCGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.57 Da        Isoelectric Point: 6.9978

>AT45024 WP_009897321.1 NZ_CP004386:157871-158725 [Burkholderia thailandensis MSMB59]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLTLAELRTLYPERALERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDASLVADGLIDKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT45024 NZ_CP004386:157871-158725 [Burkholderia thailandensis MSMB59]
ATGAGCGAGCCGCTGCTGAAGGACGCCGACGACGCGCGTAACGATTCGAACTACGTCGTGCCTGGGCTCGAGCGCGGGCT
GCGGATCCTCGCCGAGTTCTCGCCGCGCGAGCCAGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTGGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGTTTGCCGGTGATCGAGGG
CTTGCGCGACGCGACAGGCTTCACTGCGCACATCGTGATCCGCGACGGCCGCGATGTCGTGTTCGTCGCAAAGGCGCAAA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGACGCTCGCGGAGTTGCGCACGCTGTATCCGGAGCGGGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGATGCGCTGTTCGACGTGATCCGTGCCGACGCGCGCCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCAGTCGTCACGGTGACGGTGCCGAGG
CCGGAGATCGATGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTCGTGCGTGCGGCGGCCGAGCTGTCTCGGCGGCT
CAATTACCGGTCCGACGACGAAAACACCTACTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T555

Antitoxin

Source ID Structure
AlphaFold DB Q2T556

References