Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 830004..830560 Replicon chromosome
Accession NZ_CP004383
Organism Burkholderia thailandensis USAMRU Malaysia #20

Toxin (Protein)


Gene name parE Uniprot ID A0A8A8D2I2
Locus tag BTRa_RS03790 Protein ID WP_034188048.1
Coordinates 830004..830294 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8A8D2B6
Locus tag BTRa_RS03795 Protein ID WP_025369732.1
Coordinates 830282..830560 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTRa_RS32980 825891..826280 + 390 Protein_747 hypothetical protein -
BTRa_RS03760 826363..827934 - 1572 WP_009889500.1 IS66 family transposase -
BTRa_RS03765 827964..828311 - 348 WP_009889515.1 IS66 family insertion sequence element accessory protein TnpB -
BTRa_RS03770 828308..828715 - 408 WP_009888727.1 transposase -
BTRa_RS03775 828759..829295 + 537 WP_051490136.1 hypothetical protein -
BTRa_RS03780 829344..829619 - 276 WP_196587577.1 hypothetical protein -
BTRa_RS03785 829699..830007 - 309 WP_061046262.1 hypothetical protein -
BTRa_RS03790 830004..830294 - 291 WP_034188048.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTRa_RS03795 830282..830560 - 279 WP_025369732.1 CopG family ribbon-helix-helix protein Antitoxin
BTRa_RS03800 830623..831825 - 1203 WP_038712344.1 hypothetical protein -
BTRa_RS03805 831986..832255 - 270 WP_025369734.1 mobilization protein -
BTRa_RS03810 832817..833077 + 261 WP_025369735.1 hypothetical protein -
BTRa_RS03815 833142..834149 - 1008 WP_025369736.1 DUF4917 family protein -
BTRa_RS32985 834186..834467 - 282 WP_144241897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 821843..842750 20907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10968.49 Da        Isoelectric Point: 9.5558

>T45020 WP_034188048.1 NZ_CP004383:c830294-830004 [Burkholderia thailandensis USAMRU Malaysia #20]
MPQVIFAPAAIRDLQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEHYREWPIDFGDSGYVARYRLDG
ETVTILAVRHQKEAGY

Download         Length: 291 bp

>T45020 NZ_CP004383:c830294-830004 [Burkholderia thailandensis USAMRU Malaysia #20]
ATGCCGCAAGTGATCTTTGCGCCGGCGGCAATCCGAGACTTGCAACGGTTGCGCGACTTCCTGCGCCCGAAGAACCCTGA
CGCCGCGAGGCGGGCCGGCGAAGCAATTAGACAAGGCGTACAGGCTCTCGGCACCCACCCTCGAATGGGGCGTCTTGTAG
AAGACCTACCCGAGCATTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCCCGGTACCGCCTCGATGGC
GAAACCGTTACGATCTTGGCCGTCCGACATCAGAAGGAAGCGGGGTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10820.15 Da        Isoelectric Point: 5.2484

>AT45020 WP_025369732.1 NZ_CP004383:c830560-830282 [Burkholderia thailandensis USAMRU Malaysia #20]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKRETLNKDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPTPECRK

Download         Length: 279 bp

>AT45020 NZ_CP004383:c830560-830282 [Burkholderia thailandensis USAMRU Malaysia #20]
ATGGTAACAGCGACATCTATCAAGCTCGATGACGAACTGAAAGGGCGAGTACAGCACTTGGCTGAAGCGCGTCGGCGAAC
CCCGCACTGGATCATGCGCGAAGCCATCGAGCAGTACGTCGAGCGCGAGGAAAAGCGGGAGACGTTGAACAAGGACACGC
TCAAGGCGTGGGATGAGTTTCAGGCGACTGGTCTACACGCGACCGCTGAAGAAGTGGATAAGTGGCTCGCGAGCTGGGGA
ACTGAAAACGAGCTGCCCACGCCCGAATGCCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A8D2I2

Antitoxin

Source ID Structure
AlphaFold DB A0A8A8D2B6

References