45011

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 365780..366435 Replicon chromosome
Accession NZ_CP004379
Organism Burkholderia pseudomallei 1026b

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BBW_RS01655 Protein ID WP_006027262.1
Coordinates 365780..366076 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BBW_RS01660 Protein ID WP_004202809.1
Coordinates 366079..366435 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBW_RS01635 361232..361834 - 603 WP_076880366.1 site-specific DNA-methyltransferase -
BBW_RS01640 361732..362145 - 414 WP_004527843.1 phage tail protein I -
BBW_RS01645 362138..362464 - 327 WP_004552669.1 hypothetical protein -
BBW_RS01650 363236..363811 - 576 WP_198014201.1 DUF4276 family protein -
BBW_RS31705 363856..365112 - 1257 WP_004552667.1 AAA family ATPase -
BBW_RS01655 365780..366076 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBW_RS01660 366079..366435 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BBW_RS01665 366479..367534 - 1056 WP_004531045.1 phage portal protein -
BBW_RS01670 367531..369300 - 1770 WP_004531046.1 terminase ATPase subunit family protein -
BBW_RS01675 369444..370253 + 810 WP_004552664.1 GPO family capsid scaffolding protein -
BBW_RS01680 370287..371300 + 1014 WP_004531048.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 359777..401052 41275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T45011 WP_006027262.1 NZ_CP004379:365780-366076 [Burkholderia pseudomallei 1026b]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T45011 NZ_CP004379:365780-366076 [Burkholderia pseudomallei 1026b]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT45011 WP_004202809.1 NZ_CP004379:366079-366435 [Burkholderia pseudomallei 1026b]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT45011 NZ_CP004379:366079-366435 [Burkholderia pseudomallei 1026b]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References