45009

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 2873623..2874160 Replicon chromosome
Accession NZ_CP004378
Organism Burkholderia pseudomallei NAU35A-3

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag BBU_RS29315 Protein ID WP_004549731.1
Coordinates 2873891..2874160 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag BBU_RS29310 Protein ID WP_004525420.1
Coordinates 2873623..2873907 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBU_RS29285 2868731..2869993 - 1263 WP_004537187.1 c-type cytochrome -
BBU_RS29290 2870152..2871612 - 1461 WP_041222692.1 metallophosphoesterase -
BBU_RS29295 2871859..2871975 + 117 Protein_2319 IS3 family transposase -
BBU_RS38210 2872202..2872630 - 429 Protein_2320 IS110 family transposase -
BBU_RS29300 2872593..2872976 - 384 Protein_2321 DDE-type integrase/transposase/recombinase -
BBU_RS29310 2873623..2873907 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
BBU_RS29315 2873891..2874160 - 270 WP_004549731.1 BrnT family toxin Toxin
BBU_RS41030 2874482..2875213 + 732 Protein_2324 prohibitin family protein -
BBU_RS41035 2875211..2875639 + 429 Protein_2325 DDE-type integrase/transposase/recombinase -
BBU_RS39675 2876494..2877210 - 717 WP_139342045.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T45009 WP_004549731.1 NZ_CP004378:c2874160-2873891 [Burkholderia pseudomallei NAU35A-3]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T45009 NZ_CP004378:c2874160-2873891 [Burkholderia pseudomallei NAU35A-3]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT45009 WP_004525420.1 NZ_CP004378:c2873907-2873623 [Burkholderia pseudomallei NAU35A-3]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT45009 NZ_CP004378:c2873907-2873623 [Burkholderia pseudomallei NAU35A-3]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACCGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References