45005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3354303..3354958 Replicon chromosome
Accession NZ_CP004369
Organism Burkholderia pseudomallei MSHR520

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BBX_RS32015 Protein ID WP_006027262.1
Coordinates 3354303..3354599 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BBX_RS32020 Protein ID WP_004202809.1
Coordinates 3354602..3354958 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBX_RS32005 3349313..3350677 + 1365 WP_004542750.1 GGDEF domain-containing protein -
BBX_RS32010 3350788..3353037 + 2250 WP_009979045.1 glycosyltransferase -
BBX_RS39905 3352964..3353677 + 714 WP_080002914.1 cellulose biosynthesis protein BcsS -
BBX_RS32015 3354303..3354599 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBX_RS32020 3354602..3354958 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BBX_RS32025 3355002..3355151 - 150 WP_004542845.1 hypothetical protein -
BBX_RS32035 3356148..3356630 - 483 WP_020850286.1 DUF2778 domain-containing protein -
BBX_RS32040 3356700..3357599 - 900 WP_041188525.1 hypothetical protein -
BBX_RS32045 3358101..3358685 - 585 WP_020850011.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3343860..3365059 21199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T45005 WP_006027262.1 NZ_CP004369:3354303-3354599 [Burkholderia pseudomallei MSHR520]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T45005 NZ_CP004369:3354303-3354599 [Burkholderia pseudomallei MSHR520]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT45005 WP_004202809.1 NZ_CP004369:3354602-3354958 [Burkholderia pseudomallei MSHR520]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT45005 NZ_CP004369:3354602-3354958 [Burkholderia pseudomallei MSHR520]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCATGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References