Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 285390..285975 Replicon plasmid pGX5
Accession NZ_CP004365
Organism Komagataeibacter xylinus E25

Toxin (Protein)


Gene name relE Uniprot ID W5YF27
Locus tag H845_RS17740 Protein ID WP_025440186.1
Coordinates 285390..285719 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5YEQ9
Locus tag H845_RS17745 Protein ID WP_010511780.1
Coordinates 285712..285975 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H845_RS20240 281127..281519 - 393 WP_155820074.1 hypothetical protein -
H845_RS19275 282257..283675 + 1419 WP_010509887.1 phospholipase -
H845_RS19280 283820..284310 - 491 Protein_293 RES domain-containing protein -
H845_RS17730 284328..284698 - 371 Protein_294 DUF2384 domain-containing protein -
H845_RS17740 285390..285719 - 330 WP_025440186.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H845_RS17745 285712..285975 - 264 WP_010511780.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H845_RS17750 286265..286678 - 414 Protein_297 transposase -
H845_RS17755 286863..287270 + 408 WP_048883911.1 helix-turn-helix transcriptional regulator -
H845_RS19285 287267..288505 + 1239 WP_025440189.1 type II toxin-antitoxin system HipA family toxin -
H845_RS17765 288587..288949 + 363 Protein_300 helix-turn-helix domain-containing protein -
H845_RS17770 289012..289284 + 273 Protein_301 transposase -
H845_RS17775 289362..290441 + 1080 WP_025440192.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..336138 336138


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12420.07 Da        Isoelectric Point: 5.7723

>T44998 WP_025440186.1 NZ_CP004365:c285719-285390 [Komagataeibacter xylinus E25]
MTEYAIEFDDRALREWDGLDGSIRRKFEKKLEKLVLTPHSPGNELHGDLAGFYKIKLRQDGYQVVEQRIVIFVIAMGRRE
DDEIYTAATGRVPETPVTAANPGRLGTDR

Download         Length: 330 bp

>T44998 NZ_CP004365:c285719-285390 [Komagataeibacter xylinus E25]
ATGACTGAATACGCGATCGAGTTCGATGATCGTGCACTTCGGGAATGGGACGGGCTGGACGGAAGCATTCGCAGGAAATT
CGAGAAGAAGCTCGAAAAACTGGTTCTGACCCCGCATTCTCCCGGCAATGAACTGCACGGCGATCTCGCCGGATTCTACA
AAATCAAGCTTCGCCAGGACGGCTATCAGGTCGTTGAACAGAGGATCGTTATTTTTGTCATCGCGATGGGGCGCCGCGAG
GATGATGAAATCTACACGGCGGCAACAGGGCGCGTTCCGGAAACGCCAGTCACTGCTGCAAACCCTGGTAGACTTGGAAC
TGACCGATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9629.04 Da        Isoelectric Point: 7.3200

>AT44998 WP_010511780.1 NZ_CP004365:c285975-285712 [Komagataeibacter xylinus E25]
MSAVTFRVDDALKSAAVAKLSAHGLSLSDVLRDTLAYIAETGQPPVKRRLVTDEDARLIEIVRERLADPAPRHRMTLAEL
KARHPDD

Download         Length: 264 bp

>AT44998 NZ_CP004365:c285975-285712 [Komagataeibacter xylinus E25]
ATGTCCGCCGTGACATTCCGCGTCGATGACGCCCTCAAATCAGCTGCCGTTGCAAAACTCTCCGCGCACGGCCTTTCTCT
CTCCGATGTCCTGCGCGATACGTTGGCCTATATCGCCGAGACCGGCCAGCCGCCGGTAAAGCGGCGGCTTGTGACCGACG
AAGATGCTAGGCTGATCGAAATCGTCCGCGAACGCCTCGCCGATCCCGCCCCCCGCCACCGCATGACGCTGGCGGAGCTC
AAGGCCCGCCATCCCGATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W5YF27

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4J448

References