Detailed information of TA system TA044992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 789054..789595
• Replicon: chromosome
• Accession: NZ_CP004360
• Organism: Komagataeibacter xylinus E25

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H845_RS18390
• Protein ID: WP_208599488.1
• Coordinates: 789054..789356 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: W5Y756
• Locus tag: H845_RS03575
• Protein ID: WP_025437762.1
• Coordinates: 789353..789595 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H845_RS03545	784568..785944	-	1377	WP_025437756.1	HAMP domain-containing protein	-
H845_RS03550	785944..786777	-	834	WP_051459877.1	response regulator transcription factor	-
H845_RS03560	787300..787854	-	555	WP_025437759.1	class I SAM-dependent methyltransferase	-
H845_RS03565	787847..788593	+	747	WP_051459878.1	helix-turn-helix transcriptional regulator	-
H845_RS18390	789054..789356	-	303	WP_208599488.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H845_RS03575	789353..789595	-	243	WP_025437762.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
H845_RS19620	790761..791432	-	672	WP_147318789.1	hypothetical protein	-
H845_RS03585	791569..792027	-	459	WP_025437764.1	hypothetical protein	-
H845_RS18050	792142..792501	-	360	WP_157699232.1	DUF3363 domain-containing protein	-
H845_RS03590	792410..793045	-	636	WP_025437766.1	DUF3363 domain-containing protein	-
H845_RS03595	793234..793934	+	701	Protein_719	replication initiator protein A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11590.18 Da
• Isoelectric Point: 6.4776

>T44992 WP_208599488.1 NZ_CP004360:c789356-789054 [Komagataeibacter xylinus E25]
VMRFLLRPAAQADLSAIWDYSAQRWGTTQADDYVRAIGRACQDLADGTRHRQIADDIREGYLKMLVGSHLLFFRVNEDGF
IDVIRILHERMDPTRHMTDV

Nucleotide

• Length: 303 bp

>T44992 NZ_CP004360:c789356-789054 [Komagataeibacter xylinus E25]
GTGATGCGTTTTCTTTTAAGGCCAGCGGCTCAAGCCGATCTATCAGCAATCTGGGATTATTCAGCACAACGATGGGGAAC
CACTCAGGCCGACGACTATGTTCGAGCTATTGGGCGAGCCTGTCAGGATCTCGCGGACGGAACACGACATAGACAGATTG
CCGACGATATTCGGGAAGGATATCTCAAGATGCTCGTCGGTTCTCATCTGCTTTTTTTTCGGGTAAACGAAGATGGCTTT
ATCGACGTAATCCGCATCCTGCACGAACGTATGGACCCCACACGCCATATGACGGATGTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8917.93 Da
• Isoelectric Point: 4.7962

>AT44992 WP_025437762.1 NZ_CP004360:c789595-789353 [Komagataeibacter xylinus E25]
MARNTSISLGDHFADFVDQQVKGGRYGSASDVVRAGLRILEERETRLETLRSALIDGEQSGVAEPFDIEDFLTTKAKQFR

Nucleotide

• Length: 243 bp

>AT44992 NZ_CP004360:c789595-789353 [Komagataeibacter xylinus E25]
ATGGCACGCAACACATCAATCTCACTCGGCGACCATTTCGCGGATTTCGTAGACCAGCAGGTGAAAGGCGGACGCTACGG
CTCAGCGAGCGACGTCGTACGCGCTGGCCTGCGGATTCTTGAAGAGCGGGAGACACGACTTGAAACTCTTCGCTCCGCCC
TGATCGACGGCGAGCAGTCCGGTGTGGCTGAGCCGTTCGATATAGAAGATTTCCTCACCACGAAGGCTAAACAGTTCCGG
TGA

Structures

Antitoxin

• AlphaFold DB: W5Y756