Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 713477..714116 Replicon chromosome
Accession NZ_CP004118
Organism Burkholderia thailandensis E444

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag BTJ_RS19895 Protein ID WP_009893919.1
Coordinates 713937..714116 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q2T3Q7
Locus tag BTJ_RS19890 Protein ID WP_011401461.1
Coordinates 713477..713893 (-) Length 139 a.a.

Genomic Context

BTJ_RS19880BTJ_RS31330BTJ_RS19885BTJ_RS19900BTJ_RS19905BTJ_RS19910BTJ_RS19890BTJ_RS19895BTJ_RS19915
Location: 710573..711307 (735 bp)
Type: Others
Protein ID: WP_009893914.1
Location: 711360..711932 (573 bp)
Type: Others
Protein ID: WP_009893915.1
Location: 712551..713048 (498 bp)
Type: Others
Protein ID: WP_011401460.1
Location: 714396..714923 (528 bp)
Type: Others
Protein ID: WP_011401462.1
Location: 714920..715654 (735 bp)
Type: Others
Protein ID: WP_011401463.1
Location: 715664..716779 (1116 bp)
Type: Others
Protein ID: WP_009893924.1
Location: 713477..713893 (417 bp)
Type: Antitoxin
Protein ID: WP_011401461.1
Location: 713937..714116 (180 bp)
Type: Toxin
Protein ID: WP_009893919.1
Location: 716850..717425 (576 bp)
Type: Others
Protein ID: WP_009893925.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BTJ_RS19880710573..711307+735WP_009893914.1hypothetical protein-
BTJ_RS31330711360..711932+573WP_009893915.1site-specific integrase-
BTJ_RS19885712551..713048+498WP_011401460.1hypothetical protein-
BTJ_RS19890713477..713893-417WP_011401461.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BTJ_RS19895713937..714116-180WP_009893919.1type II toxin-antitoxin system HicA family toxinToxin
BTJ_RS19900714396..714923+528WP_011401462.1PAAR domain-containing protein-
BTJ_RS19905714920..715654+735WP_011401463.1VRR-NUC domain-containing protein-
BTJ_RS19910715664..716779+1116WP_009893924.1DUF3396 domain-containing protein-
BTJ_RS19915716850..717425-576WP_009893925.1recombinase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element-ddhA657518..74043882920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T44990 WP_009893919.1 NZ_CP004118:c714116-713937 [Burkholderia thailandensis E444]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T44990 NZ_CP004118:c714116-713937 [Burkholderia thailandensis E444]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGTCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.03 Da        Isoelectric Point: 4.6944

>AT44990 WP_011401461.1 NZ_CP004118:c713893-713477 [Burkholderia thailandensis E444]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGDDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT44990 NZ_CP004118:c713893-713477 [Burkholderia thailandensis E444]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GGGACGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTTGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4C26
PDB6G26

Antitoxin

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Source
ID
Structure
AlphaFold DBQ2T3Q7

References