Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2985414..2985970 Replicon chromosome
Accession NZ_CP004117
Organism Burkholderia thailandensis E444

Toxin (Protein)


Gene name parE Uniprot ID A0A8A8D2I2
Locus tag BTJ_RS30675 Protein ID WP_034188048.1
Coordinates 2985414..2985704 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8A8D2B6
Locus tag BTJ_RS13350 Protein ID WP_025369732.1
Coordinates 2985692..2985970 (-) Length 93 a.a.

Genomic Context

BTJ_RS13335BTJ_RS13365BTJ_RS13320BTJ_RS13325BTJ_RS13330BTJ_RS13340BTJ_RS13345BTJ_RS30675BTJ_RS13350BTJ_RS13355BTJ_RS13360BTJ_RS13370BTJ_RS33155
Location: 2984169..2984705 (537 bp)
Type: Others
Protein ID: WP_051490136.1
Location: 2988227..2988487 (261 bp)
Type: Others
Protein ID: WP_025369735.1
Location: 2981773..2983344 (1572 bp)
Type: Others
Protein ID: WP_009889500.1
Location: 2983374..2983721 (348 bp)
Type: Others
Protein ID: WP_009889515.1
Location: 2983718..2984125 (408 bp)
Type: Others
Protein ID: WP_009888727.1
Location: 2984754..2984954 (201 bp)
Type: Others
Protein ID: WP_025369730.1
Location: 2985109..2985417 (309 bp)
Type: Others
Protein ID: WP_061046262.1
Location: 2985414..2985704 (291 bp)
Type: Toxin
Protein ID: WP_034188048.1
Location: 2985692..2985970 (279 bp)
Type: Antitoxin
Protein ID: WP_025369732.1
Location: 2986033..2987226 (1194 bp)
Type: Others
Protein ID: WP_025369733.1
Location: 2987396..2987713 (318 bp)
Type: Others
Protein ID: WP_034188239.1
Location: 2988552..2989559 (1008 bp)
Type: Others
Protein ID: WP_025369736.1
Location: 2989596..2989877 (282 bp)
Type: Others
Protein ID: WP_144241897.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BTJ_RS133202981773..2983344-1572WP_009889500.1IS66 family transposase-
BTJ_RS133252983374..2983721-348WP_009889515.1IS66 family insertion sequence element accessory protein TnpB-
BTJ_RS133302983718..2984125-408WP_009888727.1transposase-
BTJ_RS133352984169..2984705+537WP_051490136.1hypothetical protein-
BTJ_RS133402984754..2984954-201WP_025369730.1hypothetical protein-
BTJ_RS133452985109..2985417-309WP_061046262.1hypothetical protein-
BTJ_RS306752985414..2985704-291WP_034188048.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BTJ_RS133502985692..2985970-279WP_025369732.1CopG family ribbon-helix-helix proteinAntitoxin
BTJ_RS133552986033..2987226-1194WP_025369733.1hypothetical protein-
BTJ_RS133602987396..2987713-318WP_034188239.1mobilization protein-
BTJ_RS133652988227..2988487+261WP_025369735.1hypothetical protein-
BTJ_RS133702988552..2989559-1008WP_025369736.1DUF4917 family protein-
BTJ_RS331552989596..2989877-282WP_144241897.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--2974079..299546121382


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10968.49 Da        Isoelectric Point: 9.5558

>T44988 WP_034188048.1 NZ_CP004117:c2985704-2985414 [Burkholderia thailandensis E444]
MPQVIFAPAAIRDLQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEHYREWPIDFGDSGYVARYRLDG
ETVTILAVRHQKEAGY

Download         Length: 291 bp

>T44988 NZ_CP004117:c2985704-2985414 [Burkholderia thailandensis E444]
ATGCCGCAAGTGATCTTTGCGCCGGCGGCAATCCGAGACTTGCAACGGTTGCGCGACTTCCTGCGCCCGAAGAACCCTGA
CGCCGCGAGGCGGGCCGGCGAAGCAATTAGACAAGGCGTACAGGCTCTCGGCACCCACCCTCGAATGGGGCGTCTTGTAG
AAGACCTACCCGAGCATTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCCCGGTACCGCCTCGATGGC
GAAACCGTTACGATCTTGGCCGTCCGACATCAGAAGGAAGCGGGGTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10820.15 Da        Isoelectric Point: 5.2484

>AT44988 WP_025369732.1 NZ_CP004117:c2985970-2985692 [Burkholderia thailandensis E444]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKRETLNKDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPTPECRK

Download         Length: 279 bp

>AT44988 NZ_CP004117:c2985970-2985692 [Burkholderia thailandensis E444]
ATGGTAACAGCGACATCTATCAAGCTCGATGACGAACTGAAAGGGCGAGTACAGCACTTGGCTGAAGCGCGTCGGCGAAC
CCCGCACTGGATCATGCGCGAAGCCATCGAGCAGTACGTCGAGCGCGAGGAAAAGCGGGAGACGTTGAACAAGGACACGC
TCAAGGCGTGGGATGAGTTTCAGGCGACTGGTCTACACGCGACCGCTGAAGAAGTGGATAAGTGGCTCGCGAGCTGGGGA
ACTGAAAACGAGCTGCCCACGCCCGAATGCCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A8A8D2I2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A8A8D2B6

References