44988

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2985414..2985970 Replicon chromosome
Accession NZ_CP004117
Organism Burkholderia thailandensis E444

Toxin (Protein)


Gene name parE Uniprot ID A0A8A8D2I2
Locus tag BTJ_RS30675 Protein ID WP_034188048.1
Coordinates 2985414..2985704 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8A8D2B6
Locus tag BTJ_RS13350 Protein ID WP_025369732.1
Coordinates 2985692..2985970 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTJ_RS13320 2981773..2983344 - 1572 WP_009889500.1 IS66 family transposase -
BTJ_RS13325 2983374..2983721 - 348 WP_009889515.1 IS66 family insertion sequence element accessory protein TnpB -
BTJ_RS13330 2983718..2984125 - 408 WP_009888727.1 transposase -
BTJ_RS13335 2984169..2984705 + 537 WP_051490136.1 hypothetical protein -
BTJ_RS13340 2984754..2984954 - 201 WP_025369730.1 hypothetical protein -
BTJ_RS13345 2985109..2985417 - 309 WP_061046262.1 hypothetical protein -
BTJ_RS30675 2985414..2985704 - 291 WP_034188048.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTJ_RS13350 2985692..2985970 - 279 WP_025369732.1 CopG family ribbon-helix-helix protein Antitoxin
BTJ_RS13355 2986033..2987226 - 1194 WP_025369733.1 hypothetical protein -
BTJ_RS13360 2987396..2987713 - 318 WP_034188239.1 mobilization protein -
BTJ_RS13365 2988227..2988487 + 261 WP_025369735.1 hypothetical protein -
BTJ_RS13370 2988552..2989559 - 1008 WP_025369736.1 DUF4917 family protein -
BTJ_RS33155 2989596..2989877 - 282 WP_144241897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2974079..2995461 21382


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10968.49 Da        Isoelectric Point: 9.5558

>T44988 WP_034188048.1 NZ_CP004117:c2985704-2985414 [Burkholderia thailandensis E444]
MPQVIFAPAAIRDLQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEHYREWPIDFGDSGYVARYRLDG
ETVTILAVRHQKEAGY

Download         Length: 291 bp

>T44988 NZ_CP004117:c2985704-2985414 [Burkholderia thailandensis E444]
ATGCCGCAAGTGATCTTTGCGCCGGCGGCAATCCGAGACTTGCAACGGTTGCGCGACTTCCTGCGCCCGAAGAACCCTGA
CGCCGCGAGGCGGGCCGGCGAAGCAATTAGACAAGGCGTACAGGCTCTCGGCACCCACCCTCGAATGGGGCGTCTTGTAG
AAGACCTACCCGAGCATTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCCCGGTACCGCCTCGATGGC
GAAACCGTTACGATCTTGGCCGTCCGACATCAGAAGGAAGCGGGGTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10820.15 Da        Isoelectric Point: 5.2484

>AT44988 WP_025369732.1 NZ_CP004117:c2985970-2985692 [Burkholderia thailandensis E444]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKRETLNKDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPTPECRK

Download         Length: 279 bp

>AT44988 NZ_CP004117:c2985970-2985692 [Burkholderia thailandensis E444]
ATGGTAACAGCGACATCTATCAAGCTCGATGACGAACTGAAAGGGCGAGTACAGCACTTGGCTGAAGCGCGTCGGCGAAC
CCCGCACTGGATCATGCGCGAAGCCATCGAGCAGTACGTCGAGCGCGAGGAAAAGCGGGAGACGTTGAACAAGGACACGC
TCAAGGCGTGGGATGAGTTTCAGGCGACTGGTCTACACGCGACCGCTGAAGAAGTGGATAAGTGGCTCGCGAGCTGGGGA
ACTGAAAACGAGCTGCCCACGCCCGAATGCCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A8D2I2

Antitoxin

Source ID Structure
AlphaFold DB A0A8A8D2B6

References