Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2478175..2478814 Replicon chromosome
Accession NZ_CP004098
Organism Burkholderia thailandensis 2002721723

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag BTQ_RS26955 Protein ID WP_009893919.1
Coordinates 2478635..2478814 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q2T3Q7
Locus tag BTQ_RS26950 Protein ID WP_011401461.1
Coordinates 2478175..2478591 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTQ_RS26940 2475271..2476005 + 735 WP_009893914.1 hypothetical protein -
BTQ_RS32060 2476058..2476630 + 573 WP_009893915.1 site-specific integrase -
BTQ_RS26945 2477249..2477746 + 498 WP_011401460.1 hypothetical protein -
BTQ_RS26950 2478175..2478591 - 417 WP_011401461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BTQ_RS26955 2478635..2478814 - 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin Toxin
BTQ_RS26960 2479094..2479621 + 528 WP_011401462.1 PAAR domain-containing protein -
BTQ_RS26965 2479618..2480352 + 735 WP_011401463.1 VRR-NUC domain-containing protein -
BTQ_RS26970 2480362..2481477 + 1116 WP_009893924.1 DUF3396 domain-containing protein -
BTQ_RS26975 2481548..2482123 - 576 WP_009893925.1 recombinase family protein -
BTQ_RS32070 2482445..2483425 - 981 WP_043037760.1 DUF3644 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2478175..2497745 19570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T44986 WP_009893919.1 NZ_CP004098:c2478814-2478635 [Burkholderia thailandensis 2002721723]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T44986 NZ_CP004098:c2478814-2478635 [Burkholderia thailandensis 2002721723]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGTCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.03 Da        Isoelectric Point: 4.6944

>AT44986 WP_011401461.1 NZ_CP004098:c2478591-2478175 [Burkholderia thailandensis 2002721723]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGDDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT44986 NZ_CP004098:c2478591-2478175 [Burkholderia thailandensis 2002721723]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GGGACGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTTGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4C26
PDB 6G26

Antitoxin

Source ID Structure
AlphaFold DB Q2T3Q7

References