Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 1249780..1250317 Replicon chromosome
Accession NZ_CP004098
Organism Burkholderia thailandensis 2002721723

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag BTQ_RS22080 Protein ID WP_004549731.1
Coordinates 1249780..1250049 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q2T6G1
Locus tag BTQ_RS22085 Protein ID WP_011401115.1
Coordinates 1250033..1250317 (+) Length 95 a.a.

Genomic Context

BTQ_RS22040BTQ_RS22045BTQ_RS22050BTQ_RS22055BTQ_RS22060BTQ_RS31585BTQ_RS22070BTQ_RS22075BTQ_RS22080BTQ_RS22085BTQ_RS22095BTQ_RS22100BTQ_RS22105BTQ_RS22110
Location: 1245157..1245978 (822 bp)
Type: Others
Protein ID: WP_009896491.1
Location: 1245975..1246235 (261 bp)
Type: Others
Protein ID: WP_004526650.1
Location: 1246389..1247381 (993 bp)
Type: Others
Protein ID: WP_015967393.1
Location: 1247378..1247929 (552 bp)
Type: Others
Protein ID: WP_011401112.1
Location: 1247926..1248282 (357 bp)
Type: Others
Protein ID: WP_009896497.1
Location: 1248722..1249054 (333 bp)
Type: Others
Protein ID: WP_011401114.1
Location: 1249030..1249290 (261 bp)
Type: Others
Protein ID: WP_009896498.1
Location: 1249287..1249730 (444 bp)
Type: Others
Protein ID: WP_009896499.1
Location: 1249780..1250049 (270 bp)
Type: Toxin
Protein ID: WP_004549731.1
Location: 1250033..1250317 (285 bp)
Type: Antitoxin
Protein ID: WP_011401115.1
Location: 1250948..1251427 (480 bp)
Type: Others
Protein ID: WP_025404174.1
Location: 1251427..1253169 (1743 bp)
Type: Others
Protein ID: WP_011401117.1
Location: 1253177..1254472 (1296 bp)
Type: Others
Protein ID: WP_009896509.1
Location: 1254450..1255292 (843 bp)
Type: Others
Protein ID: WP_011401119.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BTQ_RS220401245157..1245978+822WP_009896491.1hypothetical protein-
BTQ_RS220451245975..1246235+261WP_004526650.1helix-turn-helix domain-containing protein-
BTQ_RS220501246389..1247381+993WP_015967393.1hypothetical protein-
BTQ_RS220551247378..1247929+552WP_011401112.1DUF1064 domain-containing protein-
BTQ_RS220601247926..1248282+357WP_009896497.1hypothetical protein-
BTQ_RS315851248722..1249054+333WP_011401114.1hypothetical protein-
BTQ_RS220701249030..1249290+261WP_009896498.1hypothetical protein-
BTQ_RS220751249287..1249730+444WP_009896499.1hypothetical protein-
BTQ_RS220801249780..1250049+270WP_004549731.1BrnT family toxinToxin
BTQ_RS220851250033..1250317+285WP_011401115.1BrnA antitoxin family proteinAntitoxin
BTQ_RS220951250948..1251427+480WP_025404174.1terminase small subunit-
BTQ_RS221001251427..1253169+1743WP_011401117.1terminase large subunit-
BTQ_RS221051253177..1254472+1296WP_009896509.1phage portal protein-
BTQ_RS221101254450..1255292+843WP_011401119.1Clp protease ClpP-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1230348..127499144643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T44984 WP_004549731.1 NZ_CP004098:1249780-1250049 [Burkholderia thailandensis 2002721723]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T44984 NZ_CP004098:1249780-1250049 [Burkholderia thailandensis 2002721723]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10669.09 Da        Isoelectric Point: 5.8930

>AT44984 WP_011401115.1 NZ_CP004098:1250033-1250317 [Burkholderia thailandensis 2002721723]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLKEHQPA

Download         Length: 285 bp

>AT44984 NZ_CP004098:1250033-1250317 [Burkholderia thailandensis 2002721723]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTACGACGTCGACATCGTGGACGCCTTCAAGGCAACAGGCGAAGGTTGGCAGACGCGTATG
AATGATGCGTTGCGCGAGTGGCTGAAGGAGCACCAGCCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ2T6G2

Antitoxin

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Source
ID
Structure
AlphaFold DBQ2T6G1

References