44957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 454390..454972 Replicon chromosome
Accession NZ_CP004081
Organism Enterococcus faecalis DENG1

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag DENG_RS02465 Protein ID WP_002355414.1
Coordinates 454664..454972 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag DENG_RS02460 Protein ID WP_002326825.1
Coordinates 454390..454662 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DENG_RS02435 449672..450400 - 729 WP_002355404.1 GntR family transcriptional regulator -
DENG_RS02440 450577..451503 + 927 WP_002355406.1 hypothetical protein -
DENG_RS02445 451520..452803 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
DENG_RS14945 452994..453116 + 123 Protein_444 topoisomerase -
DENG_RS02450 453191..454087 + 897 WP_002363034.1 ParA family protein -
DENG_RS02455 454164..454373 + 210 WP_002363035.1 peptide-binding protein -
DENG_RS02460 454390..454662 + 273 WP_002326825.1 antitoxin Antitoxin
DENG_RS02465 454664..454972 + 309 WP_002355414.1 zeta toxin family protein Toxin
DENG_RS14950 455052..455480 - 429 WP_071623404.1 tyrosine-type recombinase/integrase -
DENG_RS02470 455525..456025 - 501 WP_002363039.1 HAD family hydrolase -
DENG_RS02475 456030..456797 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
DENG_RS02480 457284..457709 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
DENG_RS02485 457726..458241 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
DENG_RS02490 458252..459184 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL bsh / esp / psaA 422204..559658 137454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T44957 WP_002355414.1 NZ_CP004081:454664-454972 [Enterococcus faecalis DENG1]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T44957 NZ_CP004081:454664-454972 [Enterococcus faecalis DENG1]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT44957 WP_002326825.1 NZ_CP004081:454390-454662 [Enterococcus faecalis DENG1]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT44957 NZ_CP004081:454390-454662 [Enterococcus faecalis DENG1]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References