Detailed information of TA system TA044955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1209075..1209604
• Replicon: chromosome
• Accession: NZ_CP004062
• Organism: Corynebacterium glutamicum ZL-6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C627_RS15760
• Protein ID: WP_081299834.1
• Coordinates: 1209305..1209604 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1B4WJV4
• Locus tag: C627_RS05710
• Protein ID: WP_060564305.1
• Coordinates: 1209075..1209308 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C627_RS05690	1205120..1206343	-	1224	WP_004568082.1	esterase family protein	-
C627_RS05695	1206539..1207624	+	1086	WP_065366764.1	redox-regulated ATPase YchF	-
C627_RS05700	1207789..1208034	+	246	WP_060564304.1	hypothetical protein	-
C627_RS05705	1208368..1208808	+	441	WP_038583357.1	YtoQ family protein	-
C627_RS05710	1209075..1209308	+	234	WP_060564305.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
C627_RS15760	1209305..1209604	+	300	WP_081299834.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C627_RS05715	1209643..1209909	+	267	WP_087061857.1	helix-turn-helix transcriptional regulator	-
C627_RS05720	1210127..1210600	-	474	WP_081299892.1	SAP domain-containing protein	-
C627_RS05725	1210766..1211278	-	513	WP_146144404.1	hypothetical protein	-
C627_RS05730	1211498..1211956	+	459	WP_060564309.1	NUDIX domain-containing protein	-
C627_RS05735	1212120..1212503	+	384	WP_060564310.1	class I SAM-dependent methyltransferase	-
C627_RS05740	1212653..1213678	-	1026	WP_065366767.1	hypothetical protein	-
C627_RS05745	1213683..1214261	-	579	WP_060564312.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11519.03 Da
• Isoelectric Point: 10.6281

>T44955 WP_081299834.1 NZ_CP004062:1209305-1209604 [Corynebacterium glutamicum ZL-6]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGRSREEIRLGYKSTAVGSHVIFYVQRTSHW
KAMKQSVWRPTSARQFVTS

Nucleotide

• Length: 300 bp

>T44955 NZ_CP004062:1209305-1209604 [Corynebacterium glutamicum ZL-6]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCCGTAGTC
GTGAGGAAATTCGCTTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGTCATTGG
AAGGCAATGAAACAGTCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8475.39 Da
• Isoelectric Point: 4.1948

>AT44955 WP_060564305.1 NZ_CP004062:1209075-1209308 [Corynebacterium glutamicum ZL-6]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGEMSGEAEEFDFDAFIASKSS

Nucleotide

• Length: 234 bp

>AT44955 NZ_CP004062:1209075-1209308 [Corynebacterium glutamicum ZL-6]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAGAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4WJV4