Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2999971..3000625 Replicon chromosome
Accession NZ_CP004057
Organism Shigella flexneri Shi06HN006 isolate Human

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag SFYV_RS16445 Protein ID WP_000244767.1
Coordinates 2999971..3000378 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D2A730
Locus tag SFYV_RS16450 Protein ID WP_000354052.1
Coordinates 3000359..3000625 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFYV_RS16425 (2995928) 2995928..2997661 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
SFYV_RS16430 (2997667) 2997667..2998377 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SFYV_RS16435 (2998402) 2998402..2999298 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
SFYV_RS16440 (2999410) 2999410..2999931 + 522 WP_001055867.1 flavodoxin FldB -
SFYV_RS16445 (2999971) 2999971..3000378 - 408 WP_000244767.1 protein YgfX Toxin
SFYV_RS16450 (3000359) 3000359..3000625 - 267 WP_000354052.1 FAD assembly factor SdhE Antitoxin
SFYV_RS16455 (3000868) 3000868..3001848 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
SFYV_RS16460 (3002044) 3002044..3002703 - 660 WP_000250274.1 hemolysin III family protein -
SFYV_RS16465 (3002867) 3002867..3003177 - 311 Protein_2987 N(4)-acetylcytidine aminohydrolase -
SFYV_RS16470 (3003222) 3003222..3004655 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
SFYV_RS16475 (3004712) 3004712..3005455 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T44951 WP_000244767.1 NZ_CP004057:c3000378-2999971 [Shigella flexneri Shi06HN006]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T44951 NZ_CP004057:c3000378-2999971 [Shigella flexneri Shi06HN006]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.05 Da        Isoelectric Point: 5.1599

>AT44951 WP_000354052.1 NZ_CP004057:c3000625-3000359 [Shigella flexneri Shi06HN006]
MDINNKARIHWACRRGMRELDISIMSFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT44951 NZ_CP004057:c3000625-3000359 [Shigella flexneri Shi06HN006]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGTCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB D2A730

References