Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1622574..1623100 | Replicon | chromosome |
| Accession | NZ_CP004057 | ||
| Organism | Shigella flexneri Shi06HN006 isolate Human | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | SFYV_RS09010 | Protein ID | WP_000323025.1 |
| Coordinates | 1622574..1622861 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | SFYV_RS09015 | Protein ID | WP_000534858.1 |
| Coordinates | 1622861..1623100 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SFYV_RS08955 (1617632) | 1617632..1617967 | + | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
| SFYV_RS28385 (1618248) | 1618248..1618356 | - | 109 | Protein_1624 | DUF3927 family protein | - |
| SFYV_RS08980 (1619277) | 1619277..1620098 | - | 822 | WP_038404345.1 | antitermination protein | - |
| SFYV_RS08985 (1620113) | 1620113..1620469 | - | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| SFYV_RS08990 (1620482) | 1620482..1621531 | - | 1050 | WP_038404347.1 | DUF968 domain-containing protein | - |
| SFYV_RS08995 (1621533) | 1621533..1621811 | - | 279 | Protein_1628 | hypothetical protein | - |
| SFYV_RS09000 (1621878) | 1621878..1622129 | - | 252 | WP_000980987.1 | protein Rem | - |
| SFYV_RS09005 (1622347) | 1622347..1622502 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| SFYV_RS09010 (1622574) | 1622574..1622861 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| SFYV_RS09015 (1622861) | 1622861..1623100 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| SFYV_RS26220 (1623125) | 1623125..1623430 | + | 306 | WP_071818640.1 | hypothetical protein | - |
| SFYV_RS26225 (1623427) | 1623427..1624583 | - | 1157 | Protein_1634 | IS3 family transposase | - |
| SFYV_RS09030 (1624645) | 1624645..1625664 | + | 1020 | Protein_1635 | MHS family MFS transporter YdfJ | - |
| SFYV_RS09035 (1625753) | 1625753..1627213 | + | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| SFYV_RS09040 (1627249) | 1627249..1627452 | - | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1614274..1633618 | 19344 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T44940 WP_000323025.1 NZ_CP004057:c1622861-1622574 [Shigella flexneri Shi06HN006]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T44940 NZ_CP004057:c1622861-1622574 [Shigella flexneri Shi06HN006]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT44940 WP_000534858.1 NZ_CP004057:c1623100-1622861 [Shigella flexneri Shi06HN006]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT44940 NZ_CP004057:c1623100-1622861 [Shigella flexneri Shi06HN006]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|