Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1112401..1113196 | Replicon | chromosome |
| Accession | NZ_CP004057 | ||
| Organism | Shigella flexneri Shi06HN006 isolate Human | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | SFYV_RS05985 | Protein ID | WP_000854917.1 |
| Coordinates | 1112822..1113196 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2ACA1 |
| Locus tag | SFYV_RS05980 | Protein ID | WP_001280958.1 |
| Coordinates | 1112401..1112775 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SFYV_RS05940 (1107815) | 1107815..1108231 | + | 417 | WP_000275180.1 | AraC family transcriptional regulator | - |
| SFYV_RS05945 (1108290) | 1108290..1108987 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| SFYV_RS29225 (1109170) | 1109170..1109433 | + | 264 | WP_000466628.1 | DNA polymerase III subunit gamma/tau | - |
| SFYV_RS28285 (1109553) | 1109553..1109726 | + | 174 | WP_000088744.1 | DUF905 family protein | - |
| SFYV_RS05955 (1109826) | 1109826..1110647 | + | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| SFYV_RS28295 (1110989) | 1110989..1111462 | + | 474 | WP_005011597.1 | antirestriction protein | - |
| SFYV_RS05965 (1111478) | 1111478..1111954 | + | 477 | WP_005011624.1 | RadC family protein | - |
| SFYV_RS05970 (1112017) | 1112017..1112238 | + | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| SFYV_RS05980 (1112401) | 1112401..1112775 | + | 375 | WP_001280958.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| SFYV_RS05985 (1112822) | 1112822..1113196 | + | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| SFYV_RS05990 (1113193) | 1113193..1113684 | + | 492 | WP_000976828.1 | DUF5983 family protein | - |
| SFYV_RS05995 (1113696) | 1113696..1113893 | + | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| SFYV_RS06000 (1113978) | 1113978..1114540 | + | 563 | Protein_1081 | DUF4942 domain-containing protein | - |
| SFYV_RS06005 (1114612) | 1114612..1115580 | + | 969 | WP_038404411.1 | IS110-like element ISSfl8 family transposase | - |
| SFYV_RS25860 (1115902) | 1115902..1116183 | + | 282 | Protein_1083 | DUF4942 domain-containing protein | - |
| SFYV_RS06020 (1116655) | 1116655..1117593 | + | 939 | Protein_1084 | glyoxylate/hydroxypyruvate reductase GhrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1114612..1115580 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T44937 WP_000854917.1 NZ_CP004057:1112822-1113196 [Shigella flexneri Shi06HN006]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T44937 NZ_CP004057:1112822-1113196 [Shigella flexneri Shi06HN006]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13793.62 Da Isoelectric Point: 6.4651
>AT44937 WP_001280958.1 NZ_CP004057:1112401-1112775 [Shigella flexneri Shi06HN006]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT44937 NZ_CP004057:1112401-1112775 [Shigella flexneri Shi06HN006]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q93EZ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4PAV2 |