Detailed information of TA system TA044931

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3097194..3097992
• Replicon: chromosome
• Accession: NZ_CP004056
• Organism: Shigella flexneri 2003036 isolate Human

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: SFY_RS16795
• Protein ID: WP_038404245.1
• Coordinates: 3097618..3097992 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: SFY_RS16790
• Protein ID: WP_038404244.1
• Coordinates: 3097194..3097571 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFY_RS16760	3093815..3094270	+	456	WP_005051844.1	hypothetical protein	-
SFY_RS29395	3094288..3094502	+	215	Protein_3053	DUF905 family protein	-
SFY_RS16770	3094681..3095499	+	819	WP_038404242.1	DUF945 domain-containing protein	-
SFY_RS29500	3095499..3095746	+	248	Protein_3055	antirestriction protein	-
SFY_RS16775	3095841..3096314	+	474	WP_001538139.1	antirestriction protein	-
SFY_RS16780	3096330..3096806	+	477	WP_038404243.1	RadC family protein	-
SFY_RS16785	3096893..3097114	+	222	WP_000692309.1	DUF987 domain-containing protein	-
SFY_RS16790	3097194..3097571	+	378	WP_038404244.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
SFY_RS16795	3097618..3097992	+	375	WP_038404245.1	TA system toxin CbtA family protein	Toxin
SFY_RS16800	3097992..3098480	+	489	WP_038404289.1	hypothetical protein	-
SFY_RS16805	3098500..3098697	+	198	WP_000772029.1	DUF957 domain-containing protein	-
SFY_RS16810	3098782..3099624	+	843	WP_001290187.1	DUF4942 domain-containing protein	-
SFY_RS16815	3100401..3100646	+	246	WP_000875412.1	hypothetical protein	-
SFY_RS16825	3101049..3102211	+	1163	WP_094085552.1	IS3-like element IS3 family transposase	-
SFY_RS16830	3102315..3102782	-	468	WP_011069513.1	prepilin peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13854.75 Da
• Isoelectric Point: 6.2158

>T44931 WP_038404245.1 NZ_CP004056:3097618-3097992 [Shigella flexneri 2003036]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Nucleotide

• Length: 375 bp

>T44931 NZ_CP004056:3097618-3097992 [Shigella flexneri 2003036]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13754.58 Da
• Isoelectric Point: 5.5051

>AT44931 WP_038404244.1 NZ_CP004056:3097194-3097571 [Shigella flexneri 2003036]
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Nucleotide

• Length: 378 bp

>AT44931 NZ_CP004056:3097194-3097571 [Shigella flexneri 2003036]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA