Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2976209..2976863 Replicon chromosome
Accession NZ_CP004056
Organism Shigella flexneri 2003036 isolate Human

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag SFY_RS16200 Protein ID WP_000244767.1
Coordinates 2976209..2976616 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D2A730
Locus tag SFY_RS16205 Protein ID WP_000354052.1
Coordinates 2976597..2976863 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFY_RS16180 2972166..2973899 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
SFY_RS16185 2973905..2974615 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SFY_RS16190 2974640..2975536 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
SFY_RS16195 2975648..2976169 + 522 WP_001055867.1 flavodoxin FldB -
SFY_RS16200 2976209..2976616 - 408 WP_000244767.1 protein YgfX Toxin
SFY_RS16205 2976597..2976863 - 267 WP_000354052.1 FAD assembly factor SdhE Antitoxin
SFY_RS16210 2977106..2978086 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
SFY_RS16215 2978282..2978941 - 660 WP_000250274.1 hemolysin III family protein -
SFY_RS16220 2979105..2979415 - 311 Protein_2944 ASCH domain-containing protein -
SFY_RS16225 2979460..2980893 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
SFY_RS16230 2980950..2981693 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T44930 WP_000244767.1 NZ_CP004056:c2976616-2976209 [Shigella flexneri 2003036]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T44930 NZ_CP004056:c2976616-2976209 [Shigella flexneri 2003036]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.05 Da        Isoelectric Point: 5.1599

>AT44930 WP_000354052.1 NZ_CP004056:c2976863-2976597 [Shigella flexneri 2003036]
MDINNKARIHWACRRGMRELDISIMSFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT44930 NZ_CP004056:c2976863-2976597 [Shigella flexneri 2003036]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGTCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB D2A730

References