Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1603899..1604425 Replicon chromosome
Accession NZ_CP004056
Organism Shigella flexneri 2003036 isolate Human

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag SFY_RS08870 Protein ID WP_000323025.1
Coordinates 1603899..1604186 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag SFY_RS08875 Protein ID WP_000534858.1
Coordinates 1604186..1604425 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFY_RS08815 1598957..1599292 + 336 WP_000871291.1 anti-adapter protein IraM -
SFY_RS28755 1599573..1599704 - 132 Protein_1599 DUF3927 family protein -
SFY_RS08840 1600602..1601423 - 822 WP_000762882.1 antitermination protein -
SFY_RS08845 1601438..1601794 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
SFY_RS08850 1601807..1602856 - 1050 WP_001265249.1 DUF968 domain-containing protein -
SFY_RS08855 1602858..1603136 - 279 Protein_1603 hypothetical protein -
SFY_RS08860 1603203..1603454 - 252 WP_000980987.1 hypothetical protein -
SFY_RS08865 1603672..1603827 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
SFY_RS08870 1603899..1604186 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
SFY_RS08875 1604186..1604425 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
SFY_RS25795 1604450..1604755 + 306 WP_071818640.1 hypothetical protein -
SFY_RS08890 1605970..1606989 + 1020 Protein_1610 MFS transporter -
SFY_RS08895 1607078..1608538 + 1461 WP_000527804.1 mannitol dehydrogenase family protein -
SFY_RS08900 1608574..1608777 - 204 WP_000214712.1 putative selenium delivery protein YdfZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1587872..1609641 21769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T44919 WP_000323025.1 NZ_CP004056:c1604186-1603899 [Shigella flexneri 2003036]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T44919 NZ_CP004056:c1604186-1603899 [Shigella flexneri 2003036]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT44919 WP_000534858.1 NZ_CP004056:c1604425-1604186 [Shigella flexneri 2003036]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT44919 NZ_CP004056:c1604425-1604186 [Shigella flexneri 2003036]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References